Experimental and clinical evaluation of BMP2-CPC graft versus deproteinized bovine bone graft for guided bone regeneration: A pilot study.
Experimental and clinical evaluation of BMP2-CPC graft versus deproteinized bovine bone graft for guided bone regeneration: A pilot study.
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DOI：
10.4012/dmj.2019-437
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发表时间：
2020-10
影响因子：
2.5
通讯作者：
Hongzhou Shen;Yin Zhi;Fangxing Zhu;Jiawen Si;Jun Shi;S. G. Shen
中科院分区：
文献类型：
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作者：
Hongzhou Shen;Yin Zhi;Fangxing Zhu;Jiawen Si;Jun Shi;S. G. Shen
本研究将BMP-2复合磷酸钙骨水泥（BMP-2-CPC）应用于引导性骨再生（GBR），并与脱蛋白牛骨（DBB）进行了实验性骨修复和临床牙槽骨重建的比较。动物研究表明，与诱导新骨缓慢向内生长的DBB相比，BMP 2-CPC诱导了许多小的骨再生生长中心，并促进了兔颅骨缺损中大量的骨再生。BMP 2-CPC处理的缺损中残留的移植物颗粒少于DBB处理的缺损。临床研究表明，BMP-2-CPC在修复牙槽骨缺损和维持种植体稳定性方面与DBB相似。总之，本研究的结果表明，与DBB相比，BMP 2-CPC可以显著促进兔颅骨缺损的体内骨再生和重建，并为其在GBR手术中的临床应用提供了初步支持。
In this study, we proposed BMP2-incorporated calcium phosphate cement (BMP2-CPC), for application in guided bone regeneration (GBR) and compared the experimental bone restoration performance and clinical alveolar bone reconstruction outcome of BMP2-CPC with those of deproteinized bovine bone (DBB). The animal study indicated that, compared to DBB, which induced the slow ingrowth of new bone, BMP2-CPC induced numerous small growth centers for bone regeneration and facilitated a significant amount of bone regeneration in rabbit calvarial bone defects. Fewer residual graft particles remained in the BMP2-CPC-treated defects than in the DBB-treated defects. The clinical study indicated that BMP2-CPC was similar to DBB in remedying alveolar bone insufficiency and maintaining implant stability. In conclusion, the results of this present study indicate that compared to DBB, BMP2-CPC can significantly enhance in vivo bone regeneration and remodeling in rabbit calvarial bone defects and shows preliminary support on its clinical application in GBR surgeries.