A novel two-dimensional quantitative shear wave elastography to make differential diagnosis of breast lesions: Comprehensive evaluation and influencing factors
A novel two-dimensional quantitative shear wave elastography to make differential diagnosis of breast lesions: Comprehensive evaluation and influencing factors
复制标题
新型二维定量剪切波弹性成像鉴别诊断乳腺病变：综合评价及影响因素
DOI：
10.3233/ch-16188
复制
发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Fang, Yan
中科院分区：
文献类型：
--
作者：
Yao, Ming-hua;Wu, Rong;Fang, Yan
背景技术背景：虚拟触摸成像定量（VTIQ），剪切波弹性成像的一种形式，可能有助于乳腺病变的诊断。目的：我们的目的是评估联合VTIQ和常规超声（US）的诊断性能，并评估影响VTIQ测量的因素。方法：2014年9月至2014年12月，对162例乳腺病变患者进行了超声和VTIQ检查，以评估剪切波速度（SWS）和形态学特征（病变形状、方向、边缘和回声模式）。比较VTIQ、US及VTIQ+ US诊断乳腺病变的敏感性、特异性和准确性，并与病理结果进行对照。结果：SWS在恶性和良性病变之间的截断值为3.73 m/s。超声诊断的敏感性、特异性和准确性分别为98.07%、55.96%和69.57%，VTIQ诊断的敏感性、特异性和准确性分别为76.92%、78.89%和78.26%，超声+VTIQ诊断的敏感性、特异性和准确性分别为98.07%、84.40%和88.82%。影响SWS结果的两个因素是病灶边缘（OR，16.363; 95%CI，3.220-29.020）和血管分布（OR，6.712; 95%CI，1.358-9.072）。然而，VTIQ仍然是一种可靠的方法，在乳腺病变的鉴别诊断中提供了有价值的信息，并可能减少不必要的活检。
BACKGROUND: Virtual touch imaging quantification (VTIQ), a form of shear wave elastography, may help in the diagnosis of breast lesions.OBJECTIVE: We aimed to evaluate the diagnostic performance of combined VTIQ and conventional ultrasound (US), and assess the factors influencing VTIQ measurement.METHODS: From September 2014 to December 2014, 162 patients with breast lesions were examined by US and VTIQ to assess shear wave speed (SWS) and morphological characteristics (lesion shape, orientation, margin and echo pattern). The sensitivity, specificity and accuracy of VTIQ, US and VTIQ+ US for the diagnosis of breast lesions was evaluated in comparison to pathological results. Factors influencing deviations in SWS measurements were assessed by logistic regression.RESULTS: The SWS cut-off between malignant and benign lesions was 3.73 m/s. The sensitivity, specificity and accuracy were: 98.07%, 55.96%, and 69.57% for US; 76.92%, 78.89% and 78.26% for VTIQ; and 98.07%, 84.40% and 88.82% for US+VTIQ. The two factors that influenced the SWS results were the lesion margin (odds ratio [OR], 16.363; 95% confidence interval [CI], 3.220-29.020) and vascularity (OR, 6.712; 95% CI, 1.358-9.072).CONCLUSIONS: The lesion margin and vascularity could affect the measurement of SWS as well as the experience of examiner. However, VTIQ is still a reliable method that provides valuable information in the differential diagnosis of breast lesions, and may reduce unnecessary biopsies.