Shifting between response and place strategies in maze navigation: Effects of training, cue availability and functional inactivation of striatum or hippocampus in rats
Shifting between response and place strategies in maze navigation: Effects of training, cue availability and functional inactivation of striatum or hippocampus in rats
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DOI：
10.1016/j.nlm.2019.107131
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发表时间：
2020-01-01
影响因子：
2.7
通讯作者：
Cassel, Jean-Christophe
中科院分区：
文献类型：
--
作者：
Gasser, Julien;de Vasconcelos, Anne Pereira;Cassel, Jean-Christophe
反应和位置记忆系统长期以来被认为是独立的，并行编码信息，分别涉及纹状体和海马体。大多数支持这一观点的实验研究使用了简单、重复的任务，不受限制地获取空间线索。他们没有让动物有机会通过转移到一个地方来纠正反应策略，这将证明两个记忆系统在导航纠正过程中存在动态的、适应性的相互作用。在第一个实验中，大鼠在双h迷宫中接受不同持续时间（1、6或14天；4次/天）的训练，以在黑暗中（迫使反应记忆为基础的策略）或正常光照下（使反应和位置记忆系统处于平衡状态）获得重复性任务，或获得位置记忆。所有的大鼠在训练后24小时进行了一个误导性的移位探针试验，以测试它们的策略和直接纠正导航或对负反馈作出反应的能力。另外的分析集中在背纹状体和海马背侧，使用c-Fos基因表达成像，在第二个实验中，可逆的muscimol失活。结果表明，根据训练方案和持续时间的不同，纹状体（在双重策略任务中出乎意料地首先发挥作用）和海马体都需要在大鼠在提示环境中获得重复任务后纠正其导航。这些数据部分地与帕卡德和麦高建立的模型相矛盾（1996，《学习与记忆的神经生物学》，第65卷），表明记忆系统的相互作用方式比目前所认为的要复杂得多。在某种程度上，它们也挑战了海马体独立反应记忆和纹状体独立位置记忆系统的概念。
Response and place memory systems have long been considered independent, encoding information in parallel, and involving the striatum and hippocampus, respectively. Most experimental studies supporting this view used simple, repetitive tasks, with unrestrained access to spatial cues. They did not give animals an opportunity to correct a response strategy by shifting to a place one, which would demonstrate dynamic, adaptive interactions between both memory systems in the navigation correction process. In a first experiment, rats were trained in the double-H maze for different durations (1, 6, or 14 days; 4 trials/day) to acquire a repetitive task in darkness (forcing a response memory-based strategy) or normal light (placing response and place memory systems in balance), or to acquire a place memory. All rats were given a misleading shifted-start probe trial 24-h post-training to test both their strategy and their ability to correct their navigation directly or in response to negative feedback. Additional analyses focused on the dorsal striatum and the dorsal hippocampus using c-Fos gene expression imaging and, in a second experiment, reversible muscimol inactivation. The results indicate that, depending on training protocol and duration, the striatum, which was unexpectedly the first to come into play in the dual strategy task, and the hippocampus are both required when rats have to correct their navigation after having acquired a repetitive task in a cued environment. Partly contradicting the model established by Packard and McGaugh (1996, Neurobiology of Learning and Memory, vol. 65), these data point to memory systems that interact in more complex ways than considered so far. To some extent, they also challenge the notion of hippocampus-independent response memory and striatum-independent place memory systems.