Pathophysiology of Osteoporosis New Mechanistic Insights
Pathophysiology of Osteoporosis New Mechanistic Insights
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DOI：
10.1016/j.ecl.2012.04.006
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发表时间：
2012-09-01
影响因子：
4.5
通讯作者：
Recker, Robert R.
中科院分区：
文献类型：
--
作者：
Armas, Laura A. G.;Recker, Robert R.
对骨质疏松症病理生理学的理解已经发展到包括由以下几种因素引起的骨强度和骨骼脆性受损：（1）骨小梁微结构缺陷，（2）骨组织固有材料特性缺陷，（3）正常日常活动引起的微损伤修复缺陷，以及（4）过度的骨重建速率。这些因素发生在与年龄相关的骨丢失的背景下。对雌激素剥夺、抗吸收剂、机械负荷和废用的临床研究有助于进一步了解影响骨质量的因素及其机制。这一进展导致了几个新的药物靶点在治疗骨质疏松症。
Understanding of the pathophysiology of osteoporosis has evolved to include compromised bone strength and skeletal fragility caused by several factors: (1) defects in microarchitecture of trabeculae, (2) defective intrinsic material properties of bone tissue, (3) defective repair of microdamage from normal daily activities, and (4) excessive bone remodeling rates. These factors occur in the context of age-related bone loss. Clinical studies of estrogen deprivation, antiresorptives, mechanical loading, and disuse have helped further knowledge of the factors affecting bone quality and the mechanisms that underlie them. This progress has led to several new drug targets in the treatment of osteoporosis.