Elucidating effects of environmental exposure using human-induced pluripotent stem cell disease modeling.
Elucidating effects of environmental exposure using human-induced pluripotent stem cell disease modeling.
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DOI：
10.15252/emmm.202013260
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发表时间：
2022-11-08
影响因子：
11.1
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诱导多能干细胞 (iPSC) 是用于医学发现和转化研究的强大建模系统。迄今为止，大多数研究都集中在 iPSC 在再生医学、药物发现和疾病建模方面的潜力。然而，iPSC 也是一个强大的建模系统，可用于研究环境暴露对心血管系统的影响。随着电子烟、空气污染、大麻使用、阿片类药物和微塑料等新型心血管危险因素的出现，iPSC 有潜力利用传统的二维 (2D) 阵列和更先进的组织工程方法（使用类器官和其他三维 (3D) 模型）阐明这些毒素对身体的影响。遗传多态性可能会增强这些环境因素的影响，使某些个体更容易受到毒素的影响。 iPSC 疾病模型可能揭示重要的基因-环境相互作用，这种相互作用会加剧心血管疾病并使某些个体容易出现不良后果。因此，iPSC 和基因编辑技术可以在阐明基因与环境相互作用的机制以及了解个体对环境影响的易感性差异方面发挥关键作用。在这篇综述中，J Wu 及其同事讨论了人类 iPSC 作为建模系统来研究环境暴露对人类健康的毒性影响的潜力。
Induced pluripotent stem cells (iPSCs) are a powerful modeling system for medical discovery and translational research. To date, most studies have focused on the potential for iPSCs for regenerative medicine, drug discovery, and disease modeling. However, iPSCs are also a powerful modeling system to investigate the effects of environmental exposure on the cardiovascular system. With the emergence of e‐cigarettes, air pollution, marijuana use, opioids, and microplastics as novel cardiovascular risk factors, iPSCs have the potential for elucidating the effects of these toxins on the body using conventional two‐dimensional (2D) arrays and more advanced tissue engineering approaches with organoid and other three‐dimensional (3D) models. The effects of these environmental factors may be enhanced by genetic polymorphisms that make some individuals more susceptible to the effects of toxins. iPSC disease modeling may reveal important gene–environment interactions that exacerbate cardiovascular disease and predispose some individuals to adverse outcomes. Thus, iPSCs and gene‐editing techniques could play a pivotal role in elucidating the mechanisms of gene–environment interactions and understanding individual variability in susceptibility to environmental effects. In this review, J Wu and colleagues discuss the potential of human iPSC as a modeling system to investigate the toxic effects of environmental exposure on human health.