Modulators of the Balance between M1 and M2 Macrophages during Pregnancy.
Modulators of the Balance between M1 and M2 Macrophages during Pregnancy.
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怀孕期间 M1 和 M2 巨噬细胞之间平衡的调节剂
DOI：
10.3389/fimmu.2017.00120
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发表时间：
2017
影响因子：
7.3
通讯作者：
Liao AH
中科院分区：
文献类型：
--
作者：
Zhang YH;He M;Wang Y;Liao AH
巨噬细胞是先天免疫系统单核吞噬细胞的一个子集，具有高度的可塑性和异质性。在母胎界面，巨噬细胞存在于妊娠的各个阶段，并参与多种活动，包括调节免疫细胞活动、脱个体化、胎盘细胞侵袭、血管生成、分娩和产后子宫复旧。子宫-胎盘巨噬细胞的激活状态和功能在很大程度上依赖于局部组织微环境。然而，子宫微环境的破坏可对巨噬细胞活性产生深远影响，进而影响妊娠结局。因此，适当和及时调节巨噬细胞极化被认为是成功妊娠的关键决定因素。靶向巨噬细胞极化可能是维持母胎免疫稳态和正常妊娠的有效策略。在此，我们将对健康妊娠和妊娠并发症中巨噬细胞极化调节因子的最新发现进行综述，为巨噬细胞为中心的治疗策略提供依据。
Macrophages are a subset of mononuclear phagocytes of the innate immune system with high plasticity and heterogeneity. At the maternal–fetal interface, macrophages are present in all stages of pregnancy and involved in a variety of activities, including regulation of immune cell activities, decidualization, placental cell invasion, angiogenesis, parturition, and postpartum uterine involution. The activation state and function of uterine–placental macrophages are largely dependent on the local tissue microenvironment. However, disruption of the uterine microenvironment can have profound effects on macrophage activity and subsequently impact pregnancy outcome. Thus, appropriately and timely regulated macrophage polarization has been considered a key determinant of successful pregnancy. Targeting macrophage polarization might be an efficient strategy for maintaining maternal–fetal immune homeostasis and a normal pregnancy. Here, we will review the latest findings regarding the modulators regulating macrophage polarization in healthy pregnancies and pregnancy complications, which might provide a basis for macrophage-centered therapeutic strategies.