Reduction of body temperature governs neutrophil retention in hibernating and nonhibernating animals by margination
Reduction of body temperature governs neutrophil retention in hibernating and nonhibernating animals by margination
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DOI：
10.1189/jlb.0611298
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发表时间：
2013-09-01
影响因子：
5.5
通讯作者：
Kroese, Frans G. M.
中科院分区：
文献类型：
--
作者：
Bouma, Hjalmar R.;Dugbartey, George J.;Kroese, Frans G. M.
低温导致冬眠动物和非冬眠动物的循环中性粒细胞减少。冬眠由低代谢的时期组成，称为昏睡，中间穿插着恒温觉醒时期。在深度和日常（浅）休眠期间，循环白细胞的数量减少，尽管循环细胞在觉醒时恢复到正常数量。在这里，我们表明，在冬眠期间中性粒细胞减少仅仅是体温降低的结果，因为夏季恒温仓鼠和不冬眠的大鼠在强制降低体温后也会发生循环减少。脾切除术对冬眠时循环中性粒细胞的减少没有影响。中性粒细胞与血管壁的结合似乎是低温动物中性粒细胞数量减少的机制，因为地塞米松预处理抑制了这一作用。综上所述，在自然冬眠的物种或在强制低温下非冬眠的物种中，低体温会导致循环中性粒细胞减少，这是由于边缘作用。这些发现可能具有临床相关性，因为它们至少可以部分解释在创伤患者和大手术中使用治疗性低温的利弊。
Low body temperature leads to decrease of circulating neutrophils due to margination in hibernating and nonhibernating animals. Hibernation consists of periods of low metabolism, called torpor, interspersed by euthermic arousal periods. During deep and daily (shallow) torpor, the number of circulating leukocytes decreases, although circulating cells, is restored to normal numbers upon arousal. Here, we show that neutropenia, during torpor, is solely a result of lowering of body temperature, as a reduction of circulating also occurred following forced hypothermia in summer euthermic hamsters and rats that do not hibernate. Splenectomy had no effect on reduction in circulating neutrophils during torpor. Margination of neutrophils to vessel walls appears to be the mechanism responsible for reduced numbers of neutrophils in hypothermic animals, as the effect is inhibited by pretreatment with dexamethasone. In conclusion, low body temperature in species that naturally use torpor or in nonhibernating species under forced hypothermia leads to a decrease of circulating neutrophils as a result of margination. These findings may be of clinical relevance, as they could explain, at in least part, the benefits and drawbacks of therapeutic hypothermia as used in trauma patients and during major surgery.