Clinical and laboratory manifestations of Sindbis virus infection: Prospective study, Finland, 2002-2003
Clinical and laboratory manifestations of Sindbis virus infection: Prospective study, Finland, 2002-2003
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DOI：
10.1086/430007
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发表时间：
2005-06-01
影响因子：
6.4
通讯作者：
Vapalahti, O
中科院分区：
文献类型：
--
作者：
Kurkela, S;Manni, T;Vapalahti, O
信德比斯病毒（SINV）广泛分布于欧洲、非洲、澳大利亚和亚洲，但临床感染仅在少数地理上受限制的地区流行。我们最近通过从病人身上分离病毒证明，SINV是波戈斯塔病的病原体，波戈斯塔病是一种蚊子传播的皮疹关节炎，在芬兰每七年发生一次较大的流行病。在2002年爆发期间，共有86名血清学证实SINV感染的患者被招募到本研究中。我们现在详细描述不同症状的持续时间、发生率和特征；血液参数;抗体动力学;以及不同组织样本中SINV的存在。8例患者成功从血液和/或皮肤病变中检测或分离SINV RNA。免疫球蛋白（Ig） M抗体在发病的前8天检测到，IgG抗体在发病的前11天检测到。Pogosta病急性期的典型症状为关节炎、皮疹瘙痒、疲劳、轻度发热、头痛和肌肉疼痛。最显著的发现是，在50%的患者中，关节症状持续了112个月。
Sindbis virus (SINV) is widespread in Europe, Africa, Australia, and Asia, but clinical infection occurs as epidemics in a few geographically restricted areas. We recently proved, by virus isolation from patients, that SINV is the causative agent of Pogosta disease, a mosquito-borne rash-arthritis occurring as larger epidemics every seventh year in Finland. Altogether, 86 patients with serologically verified SINV infection were recruited to the present study during the 2002 outbreak. We now describe in detail the duration, incidence, and characteristics of different symptoms; hematological parameters; antibody kinetics; and presence of SINV in different tissue samples. SINV RNA detection or virus isolation from blood and/or skin lesions was successful in 8 patients. Immunoglobulin (Ig) M antibodies became detectable within the first 8 days of illness, and IgG antibodies became detectable within the first 11 days of illness. During the acute phase of Pogosta disease, the typical symptoms were arthritis, itching rash, fatigue, mild fever, headache, and muscle pain. The most notable finding was that, in 50% of the patients, joint symptoms lasted for 112 months.