Salmonella in Swine: Microbiota Interactions
Salmonella in Swine: Microbiota Interactions
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DOI：
10.1146/annurev-animal-022516-022834
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Isaacson, Richard E.
中科院分区：
文献类型：
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作者：
Kim, Hyeun Bum;Isaacson, Richard E.
对于重要的食源性病原体肠道沙门氏菌引起疾病或在猪体内持续存在，它在自身、宿主和宿主的本土微生物群之间进化出了一系列复杂的相互作用。肠沙门氏菌必须逃避宿主的免疫系统，并且还必须克服由猪的本土微生物群介导的定植抗性。针对肠沙门氏菌的炎症反应为细菌提供了独特的代谢物，因此被肠沙门氏菌利用来获得竞争优势。在感染过程中，本土微生物群落的组成发生变化，这与定植抵抗力的崩溃有关。健康猪是低水平肠沙门氏菌排出者，其本地微生物区系也表现出与患病动物相似的改变。在这里，我们回顾了有关猪、肠沙门氏菌和本地微生物区系之间相互作用的文献，并讨论了减少或预防猪肠沙门氏菌定植的方法。
For the important foodborne pathogen Salmonella enterica to cause disease or persist in pigs, it has evolved an intricate set of interactions between itself, the host, and the indigenous microflora of the host. S. enterica must evade the host's immune system and must also overcome colonization resistance mediated by the pig's indigenous microflora. The inflammatory response against S. enterica provides the bacteria with unique metabolites and is thus exploited by S. enterica for competitive advantage. During infection, changes in the composition of the indigenous microflora occur that have been associated with a breakdown in colonization resistance. Healthy pigs that are low-level shedders of S. enterica also exhibit alterations in their indigenous microflora similar to those in ill animals. Here we review the literature on the interactions that occur between swine, S. enterica, and the indigenous microflora and discuss methods to reduce or prevent colonization of pigs with S. enterica.