ANCESTRAL HAPLOTYPES - CONSERVED POPULATION MHC HAPLOTYPES
ANCESTRAL HAPLOTYPES - CONSERVED POPULATION MHC HAPLOTYPES
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DOI：
10.1016/0198-8859(92)90023-g
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发表时间：
1992-08-01
期刊：
影响因子：
2.7
通讯作者：
DAWKINS, RL
中科院分区：
文献类型：
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作者：
DEGLIESPOSTI, MA;LEAVER, AL;DAWKINS, RL
我们在这里描述了一些从HLA-B延伸到DR的高加索人MHC单倍型，这些单倍型在整体上是保守的。这些单倍型和任意两个单倍型之间的重组占我们高加索人群未选择单倍型的73%。祖先单倍型的存在意味着大染色体片段的保存。不考虑祖先单倍型保存的机制，很明显，这些单倍型携带几种MHC基因，而不是HLA，这可能与抗原呈递、自身免疫反应和移植排斥有关。鉴于祖先单倍型的存在，评估MHC与疾病和移植结果的关联，与祖先单倍型而不是单个等位基因的关联是至关重要的。
We describe here a number of Caucasoid MHC haplotypes that extend from HLA-B to DR and that have been conserved en bloc. These haplotypes and recombinants between any two of them account for 73% of unselected haplotypes in our Caucasoid population. The existence of ancestral haplotypes implies conservation of large chromosomal segments. Irrespective of the mechanisms involved in preservation of ancestral haplotypes, it is clear that these haplotypes carry several MHC genes, other than HLA, which may be relevant to antigen presentation, autoimmune responses, and transplantation rejection. In light of the existence of ancestral haplotypes, it is critical to evaluate MHC associations with disease and transplantation outcome in terms of associations with ancestral haplotypes rather than individual alleles.