Volumetric measurement of synthetic lung nodules with multi-detector row CT: Effect of various image reconstruction parameters and segmentation thresholds on measurement accuracy
Volumetric measurement of synthetic lung nodules with multi-detector row CT: Effect of various image reconstruction parameters and segmentation thresholds on measurement accuracy
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DOI：
10.1148/radiol.2353040737
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发表时间：
2005-06-01
期刊：
影响因子：
19.7
通讯作者：
Bae, KT
中科院分区：
文献类型：
--
作者：
Goo, JM;Tongdee, T;Bae, KT
目的：评价各种多排CT重建参数和结节分割阈值对合成肺结节体积测量精度的影响。材料与方法：采用多排CT扫描4种不同直径（3.2、4.8、6.4、12.7 mm）的合成肺结节。在不同的切片厚度（0.75、1.0、2.0、3.0和5.0 mm）、视场（30、20和10 cm）和重建间隔（0.5、1.0和2.0 mm）下重建图像。通过四个分割阈值（-300、-400、-500和-600 HU）从模拟的背景肺区域分割结节，通过计算绝对百分比误差（APE）估计其体积，并与参考标准（根据流体位移测量）进行比较。将APE与结节大小进行回归，并以APE为因变量和4个受试者内因素（视场、重建间隔、阈值和切片厚度）进行多变量方差分析（MANOVA）。结果：方差分析显示阈值（P.02）、切片厚度（P.02）有统计学意义
PURPOSE: To evaluate the effect of various multi-detector row computed tomographic (CT) reconstruction parameters and nodule segmentation thresholds on the accuracy of volumetric measurement of synthetic lung nodules.MATERIALS AND METHODS: Synthetic lung nodules of four different diameters (3.2, 4.8, 6.4, and 12.7 mm) were scanned with multi-detector row CT. Images were reconstructed at various section thicknesses (0.75, 1.0, 2.0, 3.0, and 5.0 mm), fields of view (30, 20, and 10 cm), and reconstruction intervals (0.5, 1.0, and 2.0 mm). The nodules were segmented from the simulated background lung region by using four segmentation thresholds (-300, -400, -500, and -600 HU), and their volumes were estimated and compared with a reference standard (measurements according to fluid displacement) by computing the absolute percentage error (APE). APE was regressed against nodule size, and multivariate analysis of variance (MANOVA) was performed with APE as the dependent variable and with four within-subject factors (field of view, reconstruction interval, threshold, and section thickness).RESULTS: The MANOVA demonstrated statistically significant effects for threshold (P.02), section thickness (P