ENERGY SUBSTRATE METABOLISM IN FRESH AND STORED HUMAN PLATELETS
ENERGY SUBSTRATE METABOLISM IN FRESH AND STORED HUMAN PLATELETS
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DOI：
10.1172/jci106210
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发表时间：
1970-01-01
影响因子：
15.9
通讯作者：
WITTELS, B
中科院分区：
文献类型：
--
作者：
COHEN, P;WITTELS, B
通过低渗孵育条件揭示了人血小板氧化几种重要的能量产生底物的潜在能力，数据表明人血小板具有相当大的氧化葡萄糖和长链脂肪酸的能力。长链脂肪酸似乎与葡萄糖一起作为潜在的能量底物。在许多哺乳动物组织中，（-）-肉毒碱用于调节长链脂肪酸被氧化的速率。人血小板在4°C下贮存24小时后，对葡萄糖的氧化能力降低约25%，对长链脂肪酸的氧化能力降低近50%。对代谢途径组成部分的研究表明，克雷布斯循环能力的显著降低可能是能量底物氧化减少的原因。图片
The latent capacity of human platelets for oxidizing several important energy-yielding substrates has been revealed by hypoosmolaric incubation conditions.The data show that the human platelet has a considerable capacity to oxidize both glucose and long-chain fatty acids. Long-chain fatty acids appear to rank favorably with glucose as a potential energy substrate. In a number of mammalian tissues, (—)-carnitine serves to regulate the rate at which long-chain fatty acids are oxidized. Evidence was obtained which suggests that (—)-carnitine functions in a similar role in the platelet.After storage of human platelets at 4°C for 24 hr, the oxidative capacity for glucose was reduced by approximately 25% and for long-chain fatty acids by almost 50%. Investigation of the component parts of the metabolic pathways indicated that a marked decrease in the capacity of the Krebs cycle could be responsible for the decrement in energy substrate oxidation.Images