Factors associated with arm swelling after breast cancer surgery
Factors associated with arm swelling after breast cancer surgery
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DOI：
10.1089/154099903770948159
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发表时间：
2003-11-01
影响因子：
3.5
通讯作者：
Secker-Walker, RH
中科院分区：
文献类型：
--
作者：
Geller, BM;Vacek, PM;Secker-Walker, RH
目的：随着乳腺癌患者寿命的延长，越来越多的女性将出现淋巴水肿症状。本研究报告了侵袭性乳腺癌手术后手臂或手部肿胀的发生率及相关危险因素。方法：收集145例浸润性乳腺癌患者的基线和随访访谈资料，以及乳腺x线摄影和病理记录。Kaplan-Meier方法用于估计随着时间的推移手臂或手肿胀的可能性。进行单因素和多因素logistic回归分析，以确定手臂或手肿胀的危险因素。结果：在这项研究中，38%的女性自我报告手臂或手肿胀。如果女性年龄在50岁以下，做过腋窝淋巴结清扫，接受过化疗，外出工作，家庭收入高，那么手臂肿胀的风险会显著增加。体重与肿胀无关联。在接受高血压治疗的女性中，手臂肿胀的风险显著降低。经淋巴结清扫调整后，只有年龄有显著的独立影响。结论：我们的研究强调了未来研究的两个重要领域，可以减少淋巴水肿的发病率。有必要更好地了解高血压治疗在保护女性免受手臂水肿方面可能发挥的作用。其次，鉴于不同研究的结果相互矛盾，体重作为可改变的淋巴水肿危险因素的潜在影响需要进行更详细的研究。
Purpose: As life expectancy improves for women with breast cancer, more women will be living with symptoms of lymphedema. This study reports the incidence of arm or hand swelling and associated risk factors in women with invasive breast cancer following surgery.Methods: Data were obtained from baseline and follow-up interviews of women with invasive breast cancer (n = 145), and mammography and pathology records. The Kaplan-Meier method was used to estimate the probability of developing arm or hand swelling over time. Univariate and multivariate logistic regression analyses were conducted to identify risk factors for arm or hand swelling.Results: Of women in this study, 38% self-reported arm or hand swelling. There was a significantly increased risk of arm swelling if women were under 50 years of age, had axillary node dissection, received chemotherapy, worked outside the home, and had a high household income. There was no association of body weight with swelling. A significantly decreased risk of arm swelling was found in women who were on treatment for high blood pressure. After adjustment for nodal dissection, only age had a significant independent effect.Conclusions: Our study highlights two important areas of future research that could reduce the incidence of lymphedema. There is a need to better understand the role that treatment for high blood pressure may play in protecting women from arm edema. Second, the potential effect of weight as a modifiable lymphedema risk factor needs to be studied in more detail in light of the conflicting results of different studies.