The effects of pharmacological manipulations that influence vagal control of the heart on heart period, heart-period variability and respiration in rats.
The effects of pharmacological manipulations that influence vagal control of the heart on heart period, heart-period variability and respiration in rats.
复制标题
影响心脏迷走神经控制的药理操作对大鼠心率、心率变异性和呼吸的影响。
DOI：
10.1111/j.1469-8986.1982.tb02499.x
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发表时间：
1982
期刊：
影响因子：
3.7
通讯作者：
Ackles,PK
中科院分区：
文献类型：
--
作者：
Yongue,BG;McCabe,PM;Porges,SW;Rivera,M;Kelley,SL;Ackles,PK
在已知影响心脏迷走神经控制的药物操作后，检查自由活动大鼠的心脏周期（HP）、心脏周期方差（HPV）和 HPV 呼吸成分的变化。光谱分析用于量化与呼吸相关的 HPV 成分，该成分对迷走神经对心脏的影响敏感。 HPV 的呼吸成分由统计量 V̌ 描述，它是与正常呼吸相关的频段上的心跳周期频谱的频谱密度之和。迷走神经张力被去氧肾上腺素反射性增强，或被阿托品外周阻断。去氧肾上腺素产生 HP 和 V̌ 的双相变化，增加持续 0.5 至 2 小时。阿托品导致 HP、HPV 和 V̌ 显着降低。尽管 HP 和 HPV 较初始注射后值显着线性增加，但这些下降在整个实验过程中是立即且持续的。在盐水条件下，HP 随着时间的推移呈线性增加。结果根据心脏的迷走神经和非迷走神经控制进行了讨论。有人提出，虽然所有三个变量都会通过控制迷走神经对心脏的影响而改变，但与 HP 和 HPV 相比，V̌ 受非迷走神经控制的影响似乎较小。
Changes in heart period (HP), heart‐period variance (HPV), and the respiratory component of HPV in freely moving rats were examined following pharmacological manipulations known to influence vagal control of the heart. Spectral analysis was used to quantify the component of HPV associated with respiration which is proposed to be sensitive to vagal influences on the heart. The respiratory component of HPV is described by a statistic, V̌, which is the sum of the spectral densities of the heart period spectrum across the band of frequencies associated with normal respiration. Vagal tone was reflexively enhanced by phenylephrine or peripherally blocked by atropine.Phenylephrine produced biphasic changes in HP and V̌, with the increases lasting from 0.5 to 2 hrs. Atropine resulted in significant decreases in HP, HPV and V̌. These decreases were immediate and sustained throughout the experiment, although there were signiflcant linear increases in HP and HPV from their initial post‐injection values. In the saline condition, HP increased linearly across time.Results were discussed in terms of vagal and non‐vagal control of the heart. It was suggested that, while all three variables are altered by manipulations of vagal influences on the heart, V̌ seems to be influenced less by non‐vagal control than HP and HPV.