EFFECT OF WHEAT FIBER AND VITAMIN-C AND VITAMIN-E ON RECTAL POLYPS IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS
EFFECT OF WHEAT FIBER AND VITAMIN-C AND VITAMIN-E ON RECTAL POLYPS IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS
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DOI：
10.1093/jnci/81.17.1290
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发表时间：
1989-09-06
影响因子：
10.3
通讯作者：
LESSER, ML
中科院分区：
文献类型：
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作者：
DECOSSE, JJ;MILLER, HH;LESSER, ML
在对大肠瘤形成的化学预防试验中，在4年的时间内，用4g抗坏血酸（维生素C）/天加400 mg α-羟丁酸治疗58名患有家族性腺瘤性息肉病的患者。生育酚（维生素E）/天单独或与谷物纤维补充剂（22.5克/天）。在这项随机双盲、安慰剂对照研究中，我们确定了这些补充剂对这些患者直肠息肉的影响。意向治疗分析表明，高纤维补充剂的效果有限。根据患者依从性调整的分析显示，在试验的中间2年期间，高纤维补充剂的益处更大。结果提供了在本研究人群中通过超过11 g/天的谷物纤维补充剂抑制良性大肠肿瘤的证据。这些发现与以下假设一致：膳食谷物纤维和总膳食脂肪在大肠肿瘤的发生中起竞争变量的作用。
Over a 4-year period in a chemoprevention trial on large bowel neoplasia, 58 patients with familial adenomatous polyposis were treated with 4 g of ascorbic acid (vitamin C)/day plus 400 mg of .alpha.-tocopherol (vitamin E)/day alone or with a grain fiber supplement (22.5 g/day). In this randomized double-blind, placebo-controlled study, we determined the effects of these supplements on rectal polyps in these patients. Analysis by intent to treat suggested that the high-fiber supplement had a limited effect. Analysis adjusted for patient compliance showed a stronger benefit from the high-fiber supplement during the middle 2 years of the trial. The results provide evidence for inhibition of benign large bowel neoplasia by grain fiber supplements in excess of 11 g/day in this study population. The findings are consistent with the hypothesis that dietary grain fiber and total dietary fat act as competing variables in the genesis of large bowel neoplasia.