Adsorption of chlorhexidine onto cellulosic fibers
Adsorption of chlorhexidine onto cellulosic fibers
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DOI：
10.1007/s10570-009-9281-5
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发表时间：
2009-02
期刊：
影响因子：
5.7
通讯作者：
E. Giménez-Martín;M. López-Andrade;A. Ontiveros-Ortega;M. Espinosa‐Jiménez
中科院分区：
文献类型：
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作者：
E. Giménez-Martín;M. López-Andrade;A. Ontiveros-Ortega;M. Espinosa‐Jiménez
本文研究了氯己定（CHX）在漂白棉和粘胶两种纤维素纤维上的吸附性能，以获得已知量的氯己定覆盖的干纱布。在293和323 K下的吸附等温线可以用Langmuir等温模型描述，但在高浓度下，Freundlich等温模型的相关性更好。随着CHX浓度的电动势演变表明，棉花和粘胶的初始负ζ电位随着处理浓度的增加而减小其绝对值;两种纤维在高浓度的CHX下均呈现等电点，对于粘胶为0.3mM，对于棉花为0.8mM。CHX的阳离子基团和纤维的羧酸基团之间的静电相互作用可以解释在低浓度下的吸附，但是当它高于这些值时，CHX的胺基和纤维素的羟基之间可能的氢键可以解释当它被静电排斥阻碍时增加的吸附，正如Freundlich模型所预测的那样，该模型描述了非均质表面和多层吸附。吸附动力学等温线表明，吸附过程是快速的，1/2值为5.4分钟棉和粘胶2.8分钟。两种纤维之间的吸附行为的差异可以归因于结构差异，因为我们已经观察到从基于FTIR光谱的CI指数估计。获得的值为1.6的粘胶和2.2的棉花可以解释吸附在粘胶上的CHX的量高于它是在棉花上。最后，在室温和pH 6下用0.01 M NaCl溶液进行的解吸实验揭示了这些纤维的治疗应用的可能性，尽管必须进行进一步的研究以优化该过程。
Comparative investigations of adsorption properties of chlorhexidine (CHX) on two cellulose fibers, bleached cotton and viscose, were studied in order to obtain dry gauzes covered with known amount of this antiseptic. Adsorption isotherm results carried out at 293 and 323 K can be described by Langmuir isotherm model, nevertheless, at high concentration correlation is better to Freundlich isotherm. Electrokinetic potential evolution with CHX concentration, shows that initial negative zeta potential of cotton and viscose diminish its absolute value as the concentration of the treatment increases; both fibers present an isoelectric point at high concentration of CHX that is 0.3 mM for viscose and 0.8 mM for cotton. Electrostatic interactions between cationic groups of CHX and carboxylic acid groups of the fibers could explain adsorption at low concentration, but when it is higher than these values, possible hydrogen bonding between the amine groups of CHX and hydroxyl groups of cellulose could explain increasing adsorption when it is hindered by electrostatic repulsion as it is predicted by Freundlich model, that describes heterogeneous surface and multilayer adsorption. Adsorption kinetics isotherms reveal that the process is quick witht1/2values of 5.4 min for cotton and 2.8 min for viscose. Differences in adsorption behaviour between the two fibers could be attributed to structural differences as we have observed from estimation of CI index based on FTIR spectra. Values obtained 1.6 for viscose and 2.2 for cotton could explain that the amount of CHX adsorbed on viscose is higher than it is on cotton. Finally desorption experiments performed with 0.01 M of NaCl solution at room temperature and pH 6 reveals the possibility of therapeutical application of these fibers although further investigations must be done to optimize the process.