Organelle-Specific Autophagy in Cellular Aging and Rejuvenation.
Organelle-Specific Autophagy in Cellular Aging and Rejuvenation.
复制标题
DOI：
10.20900/agmr20210010
复制
发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Bohnert, K Adam
中科院分区：
文献类型：
--
作者：
Butsch, Tyler J;Ghosh, Bhaswati;Bohnert, K Adam
细胞的健康需要细胞器的适当功能、调节和质量控制，细胞器是细胞内执行其基本生化任务的膜封闭的隔间。衰老通常会扰乱细胞器的动态平衡，导致细胞健康问题，从而刺激退行性疾病和相关病理的开始和进展。在这里，我们讨论新的证据表明，与年龄相关的细胞器稳态缺陷部分源于自噬-溶酶体系统的功能障碍，自噬-溶酶体系统是细胞质量控制和损伤清除的关键角色。我们还重点介绍了生物学中的自然例子，其中自噬-溶酶体系统的增强活性可能被利用来消除与年龄相关的细胞器损伤，从而提高对细胞复兴的潜在影响。
The health of a cell requires proper functioning, regulation, and quality control of its organelles, the membrane-enclosed compartments inside the cell that carry out its essential biochemical tasks. Aging commonly perturbs organelle homeostasis, causing problems to cellular health that can spur the initiation and progression of degenerative diseases and related pathologies. Here, we discuss emerging evidence indicating that age-related defects in organelle homeostasis stem in part from dysfunction of the autophagy-lysosome system, a pivotal player in cellular quality control and damage clearance. We also highlight natural examples from biology where enhanced activity of the autophagy-lysosome system might be harnessed to erase age-related organelle damage, raising potential implications for cellular rejuvenation.