Recent Progress on the Versatility of Virus-Like Particles
Recent Progress on the Versatility of Virus-Like Particles
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DOI：
10.3390/vaccines8010139
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发表时间：
2020
期刊：
影响因子：
7.8
通讯作者：
Ningshao Xia
中科院分区：
文献类型：
--
作者：
Ciying Qian;Xinlin Liu;Qin Xu;Zhiping Wang;Jie Chen;Tingting Li;Qingbing Zheng;Hai Yu;Ying Gu;Shaowei Li;Ningshao Xia
Virus-like particles (VLPs) are multimeric nanostructures composed of one or more structural proteins of a virus in the absence of genetic material. Having similar morphology to natural viruses but lacking any pathogenicity or infectivity, VLPs have gradually become a safe substitute for inactivated or attenuated vaccines. VLPs can achieve tissue-specific targeting and complete and effective cell penetration. With highly ordered epitope repeats, VLPs have excellent immunogenicity and can induce strong cellular and humoral immune responses. In addition, as a type of nanocarrier, VLPs can be used to display antigenic epitopes or deliver small molecules. VLPs have thus become powerful tools for vaccinology and biomedical research. This review highlights the versatility of VLPs in antigen presentation, drug delivery, and vaccine technology.
