Electronic signature of DNA nucleotides via transverse transport
Electronic signature of DNA nucleotides via transverse transport
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DOI：
10.1021/nl048289w
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发表时间：
2005-03-01
期刊：
影响因子：
10.8
通讯作者：
Di Ventra, M
中科院分区：
文献类型：
--
作者：
Zwolak, M;Di Ventra, M
我们报告的理论研究中的单链DNA中的电荷传输方向垂直于骨干轴。我们发现，如果夹着DNA的电极具有适当的空间宽度，由于四种碱基的不同电子和化学结构，每个核苷酸都携带着独特的签名。该特征不依赖于最近邻核苷酸。此外，除了与鸟嘌呤和胞嘧啶碱基的核苷酸，我们发现，核苷酸的电导的差异是大的碱基相对于电极的大多数取向。通过利用这些差异，有可能通过用导电探针扫描单链DNA的长度来对其进行测序。
We report theoretical studies of charge transport in single-stranded DNA in the direction perpendicular to the backbone axis. We find that, if the electrodes which sandwich the DNA have the appropriate spatial width, each nucleotide carries a unique signature due to the different electronic and chemical structure of the four bases. This signature is independent of the nearest-neighbor nucleotides. Furthermore, except for the nucleotides with guanine and cytosine bases, we find that the difference in conductance of the nucleotides is large for most orientations of the bases with respect to the electrodes. By exploiting these differences it may be possible to sequence single-stranded DNA by scanning its length with conducting probes.