Focal And Global Brain Measurements in Siblings of Patients With Schizophrenia
Focal And Global Brain Measurements in Siblings of Patients With Schizophrenia
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DOI：
10.1093/schbul/sbq147
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发表时间：
2012-06-01
影响因子：
6.6
通讯作者：
Kahn, Rene S.
中科院分区：
文献类型：
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作者：
Boos, Heleen B. M.;Cahn, Wiepke;Kahn, Rene S.
背景：目前尚不清楚精神分裂症的脑结构异常是否由遗传和/或疾病相关因素引起。在精神分裂症患者的非精神病一级亲属中发现了脑结构异常，但结果并不确定。这项大型磁共振成像研究使用整体和局部脑测量检查了精神分裂症患者及其非精神病同胞和健康对照受试者的脑结构。研究方法：对155名精神分裂症患者、他们的186名非精神病同胞和122名健康对照者（包括25对同胞）进行了全脑扫描。获得全脑、灰质（GM）和大脑的白色物质、侧脑室和第三脑室以及小脑体积的分段。对于每一个主题，皮质厚度和GM密度图的措施进行了估计。使用结构方程模型分析体积、皮质厚度和GM密度的组差异，从而控制数据的家族依赖性。结果如下：精神分裂症患者，而不是他们的非精神病同胞，表现出体积差异，皮质变薄，并减少GM密度与对照组相比。结论：本研究使用多种成像方法，与健康对照受试者相比，精神分裂症患者的非精神病同胞没有发现脑结构异常。因此，在精神分裂症患者中观察到的脑结构异常在很大程度上是由疾病相关因素解释的。
Background: It remains unclear whether structural brain abnormalities in schizophrenia are caused by genetic and/or disease-related factors. Structural brain abnormalities have been found in nonpsychotic first-degree relatives of patients with schizophrenia, but results are inconclusive. This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements. Methods: From 155 patients with schizophrenia, their 186 nonpsychotic siblings, and 122 healthy controls (including 25 sibling pairs), whole-brain scans were obtained. Segmentations of total brain, gray matter (GM), and white matter of the cerebrum, lateral and third ventricle, and cerebellum volumes were obtained. For each subject, measures of cortical thickness and GM density maps were estimated. Group differences in volumes, cortical thickness, and GM density were analyzed using Structural Equation Modeling, hence controlling for familial dependency of the data. Results: Patients with schizophrenia, but not their nonpsychotic siblings, showed volumetric differences, cortical thinning, and reduced GM density as compared with control subjects. Conclusions: This study did not reveal structural brain abnormalities in nonpsychotic siblings of patients with schizophrenia compared with healthy control subjects using multiple imaging methods. Therefore, the structural brain abnormalities observed in patients with schizophrenia are for the largest part explained by disease-related factors.