A model of atropine-resistant theta oscillations in rat hippocampal area CA1
A model of atropine-resistant theta oscillations in rat hippocampal area CA1
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DOI：
10.1113/jphysiol.2002.024588
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发表时间：
2002-09-15
影响因子：
5.5
通讯作者：
Whittington, MA
中科院分区：
文献类型：
--
作者：
Gillies, MJ;Traub, RD;Whittington, MA
θ频率振荡是海马体节律性活动的主要特征。我们证明，在AMPA受体激活减少的情况下，海马区CA1产生阿托品抗性theta种群振荡，以响应代谢性谷氨酸受体激活。这种活动发生在没有来自CA3区和超氨区输入的情况下。场θ振荡与锥体远端顶端树突突发峰共表达，并与ipsp序列有时间上的慢动力学关系。锥体体反应表明，theta振荡由具有初始IPSPs的复合抑制性突触电位组成，其动力学缓慢，随后是一系列更小、更快的IPSPs。ipsp的药理学调节改变了θ振荡，表明抑制网络起源。体细胞ipsp、树突突放电和金字塔层中间神经元的活动都与东方层中间神经元的峰值在时间上相关，表现出固有的θ频率振荡。这些中间神经元的峰值中断伴随着波场和波频率的IPSP序列的丢失。我们认为群体θ振荡可能是由于控制锥体细胞顶端树突电发生的一组中层中间神经元的固有θ频率尖峰活动而产生的。
Theta frequency oscillations are a predominant feature of rhythmic activity in the hippocampus. We demonstrate that hippocampal area CA1 generates atropine-resistant theta population oscillations in response to metabotropic glutamate receptor activation under conditions of reduced AMPA receptor activation. This activity occurred in the absence of inputs from area CA3 and extra-ammonic areas. Field theta oscillations were co-expressed with pyramidal distal apical dendritic burst spiking and were temporally related to trains of IPSPs with slow kinetics. Pyramidal somatic responses showed theta oscillations consisted of compound inhibitory synaptic potentials with initial IPSPs with slow kinetics followed by trains of smaller, faster IPSPs. Pharmacological modulation of IPSPs altered the theta oscillation suggesting an inhibitory network origin. Somatic IPSPs, dendritic burst firing and stratum pyramidale interneuron activity were all temporally correlated with spiking in stratum oriens interneurons demonstrating intrinsic theta-frequency oscillations. Disruption of spiking in these interneurons was accompanied by a loss of both field theta and theta frequency IPSP trains. We suggest that population theta oscillations can be generated as a consequence of intrinsic theta frequency spiking activity in a subset of stratum oriens interneurons controlling electrogenesis in pyramidal cell apical dendrites.