Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: The contributions of novel receptor-activity-modifying proteins
Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: The contributions of novel receptor-activity-modifying proteins
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DOI：
10.1080/10606820213683
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Muff, R
中科院分区：
文献类型：
--
作者：
Born, W;Fischer, JA;Muff, R
受体活性修饰蛋白（RAMP）的发现揭示了G蛋白偶联受体功能的新原理。最初的孤儿降钙素受体样受体（CRLR）与RAMP1共表达时被鉴定为CGRP受体。在RAMP2存在时，同一受体对肾上腺髓质素（ADM）具有特异性。与CRLR具有60%同源性的降钙素受体（CTR）在没有RAMP的情况下主要识别降钙素。当降钙素受体（CTR）与RAMP1共表达时，amylin/CGRP受体被识别。在RAMP3存在的情况下，CTR仅与胰淀素相互作用。RAMP与CRLR或CTR的非共价结合揭示了细胞表面的异二聚体RAMP/受体复合物。因此，两种II类G蛋白偶联受体CRLR和CTR与三种RAMP结合，形成对CGRP、ADM或amylin的高亲和力受体。本文就这些受体的分子组成和功能特性作一综述。
The discovery of receptor-activity-modifying proteins (RAMP) revealed a new principle for the function of G protein-coupled receptors. The initially orphan calcitonin receptor-like receptor (CRLR) was identified as a CGRP receptor when coexpressed with RAMP1. The same receptor is specific for adrenomedullin (ADM) in the presence of RAMP2. Calcitonin receptors (CTR) with 60% homology to the CRLR predominantly recognize calcitonin in the absence of RAMP. An amylin/CGRP receptor was recognized when a calcitonin receptor (CTR) was coexpressed with RAMP1. In the presence of RAMP3, the CTR only interacts with amylin. Noncovalent association of the RAMP with the CRLR or the CTR reveals heterodimeric RAMP/receptor complexes at the cell surface. Thus, two Class II G protein-coupled receptors, the CRLR and CTR, associate with three RAMP to form high affinity receptors for CGRP, ADM, or amylin. Here, the molecular composition and the functional properties of these receptors is reviewed.