Curvulamine, a New Antibacterial Alkaloid Incorporating Two Undescribed Units from a Curvularia Species
Curvulamine, a New Antibacterial Alkaloid Incorporating Two Undescribed Units from a Curvularia Species
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Curvulamine，一种新型抗菌生物碱，包含来自弯孢菌属物种的两个未描述的单位
DOI：
10.1021/ol502572g
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发表时间：
2014-10-17
期刊：
影响因子：
5.2
通讯作者：
Tan, Ren Xiang
中科院分区：
文献类型：
--
作者：
Han, Wen Bo;Lu, Yan Hua;Tan, Ren Xiang
白花鱼(ArgyroSomus Argentatus)来源于弯孢霉属(Curveraria sp.)IFB-Z10作为一种骨骼史无前例的生物碱，结合了两个未描述的延伸剂单元，产生了古鲁瓦胺。柯维拉明比替硝唑更有选择性地抗菌，并且在生物合成上是独一无二的，这些新的延长剂是通过寡酮基序和丙氨酸之间的脱羧基缩合形成的。
The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.