Patient-specific time to peak abdominal organ enhancement varies with time to peak aortic enhancement at MR imaging
Patient-specific time to peak abdominal organ enhancement varies with time to peak aortic enhancement at MR imaging
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DOI：
10.1148/radiol.2451061585
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发表时间：
2007-12-01
期刊：
影响因子：
19.7
通讯作者：
Yeh, Benjamin M.
中科院分区：
文献类型：
--
作者：
Chu, Lisa L.;Joe, Bonnie N.;Yeh, Benjamin M.
目的：回顾性评估肝脏、胰腺和空肠增强峰值时间与磁共振(MR)主动脉增强峰值时间之间的关系。材料和方法：人类研究委员会批准了这项研究，并放弃了书面知情同意。这项研究符合HIPAA标准。这项研究回顾了141名接受腹部磁共振成像的患者(男性63名，女性78名；平均年龄57岁)，他们使用测试剂进行腹部磁共振成像，测试剂大约每秒监测一次，持续2分钟，上腹部有一个损坏的梯度回波T1横切面。通过单因素和多因素线性回归分析，记录主动脉、肝脏、胰腺和空肠的强化达峰时间，并与主动脉强化达峰时间、年龄和性别相关。结果：主动脉强化达峰的平均时间为21.1秒(8.7-41.8秒)。肝脏、胰腺和空肠的强化峰值时间与主动脉强化峰值时间呈线性正相关(r分别为0.69、0.86和0.80，均P<0.01)，分别是主动脉强化峰值时间的3.39、1.64和2.04倍。年龄、性别和心脏病病史没有提供额外的预测信息来确定内脏强化达到峰值的时间。结论：肝脏、胰腺和空肠的强化达到峰值的时间与主动脉的强化达到峰值的时间呈线性相关。这些结果可能使对比剂增强MR图像评估中针对患者和器官的特定扫描延迟优化成为可能。
Purpose: To retrospectively evaluate the relationship between the times to peak enhancement of the liver, pancreas, and jejunum with respect to the time to peak aortic enhancement at magnetic resonance (MR) imaging.Materials and Methods: The committee on human research approved this study and waived written informed consent. This study was HIPAA compliant. The study retrospectively identified 141 patients (63 men, 78 women; mean age, 57 years) who underwent abdominal MR imaging by using a test bolus that was monitored approximately every second for 2 minutes with a spoiled gradient-echo T1 transverse section through the upper abdomen. The times to peak enhancement of the aorta, liver, pancreas, and jejunum were recorded and correlated with the time to peak aortic enhancement, age, and sex by means of univariate and multivariate linear regression analyses.Results: The mean time to peak aortic enhancement was 21.1 seconds (range, 8.7-41.8 seconds). The times to peak enhancement of the liver, pancreas, and jejunum were positively and linearly correlated with the time to peak aortic enhancement (r = 0.69, 0.86, and 0.80, respectively, all P < .001) and were 3.39, 1.64, and 2.04 times longer than the time to peak aortic enhancement, respectively. Age, sex, and history of heart disease did not give additional predictive information for determining the time to peak visceral enhancement.Conclusion: The times to peak enhancement of the liver, pancreas, and jejunum are linearly related to that of the aorta. These results could potentially allow tailored patient- and organ-specific scan delay optimization at contrast material enhanced MR image evaluation.