Microbiome Contributions to Health.
Microbiome Contributions to Health.
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DOI：
10.1089/sur.2023.002
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发表时间：
2023-04
影响因子：
2
通讯作者：
Tyler Reynolds;Soroosh Noorbakhsh;Randi N Smith
中科院分区：
文献类型：
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作者：
Tyler Reynolds;Soroosh Noorbakhsh;Randi N Smith
人体微生物组是巨大的，存在于以前被认为是无菌的空间，如肺部。健康的微生物组是多样的，并以适应性的方式发挥作用，以支持当地以及有机体的健康和功能。此外，正常的微生物组对于正常的免疫系统发育至关重要，使得生活在人体内和人体上的微生物阵列成为体内平衡的关键组成部分。一系列广泛的临床状况和干预措施，包括麻醉、镇痛和手术干预，可能会以适应不良的方式扰乱人类微生物组，细菌反应从多样性降低到转化为致病性表型。在此，我们探索皮肤，胃肠道和肺部的正常微生物组作为原型站点，以描述这些位置中每个位置的微生物组对健康的影响，以及护理如何破坏这些关系。
The human microbiome is vast and is present in spaces previously thought to be sterile such as the lungs. A healthy microbiome is diverse and functions in an adaptive way to support local as well as organism health and function. Furthermore, a normal microbiome is essential for normal immune system development rendering the array of microbes that live in and on the human body key components of homeostasis. A wide array of clinical conditions and interventions including anesthesia, analgesia, and surgical intervention may derange the human microbiome in a maladaptive fashion with bacterial responses spanning decreased diversity to transformation to a pathogenic phenotype. Herein, we explore the normal microbiome of the skin, gastrointestinal tract, and the lungs as prototype sites to describe the influence of the microbiomes in each of those locations on health, and how care may derange those relations.