p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells
p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells
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DOI：
10.1016/j.bbrc.2007.11.051
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发表时间：
2008-01-25
影响因子：
3.1
通讯作者：
Groesch, Sabine
中科院分区：
文献类型：
--
作者：
Janssen, Astrid;Schiffmann, Susanne;Groesch, Sabine
S-ibuprofen which inhibits the cyclooxygenase-1/-2 and R-ibuprofen which shows no COX-inhibition at therapeutic concentrations have anti-carcinogenic effects in human colon cancer cells; however, the molecular mechanisms for these effects are still unknown. Using HCT-116 colon carcinoma cell lines, expressing either the wild-type form of p53 (HCT-116 p53(wt)) or being p(HCT-116 p53(-/-)), we demonstrated that both induction of a cell cycle block and apoptosis after S- and R-ibuprofen treatment is in part dependent on p53. Also in the in vivo nude mice model HCT-116 p53(-/-) xenografts were less sensitive for S- and R-ibuprofen treatment than HCT-116 p53(wt) cells. Furthermore, results indicate that induction of apoptosis in HCT-116 p53(wt) cells after ibuprofen treatment is in part dependent on a signalling pathway including the neutrophin receptor p75(NTR), p53 and Bax. (c) 2007 Elsevier Inc. All rights reserved.
