Subcutaneous tissue mechanical behavior is linear and viscoelastic under uniaxial tension
Subcutaneous tissue mechanical behavior is linear and viscoelastic under uniaxial tension
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DOI：
10.1080/03008200390244069
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发表时间：
2003-10-01
影响因子：
2.9
通讯作者：
Langevin, HM
中科院分区：
文献类型：
--
作者：
Iatridis, JC;Wu, JR;Langevin, HM
皮下组织是全身“疏松”结缔组织网络的一部分，包括分隔肌肉并包围所有神经和血管的间质结缔组织。尽管它在体内无处不在，并且在利用机械拉伸以及正常运动和锻炼的各种治疗中具有潜在的重要性，但人们对疏松结缔组织的生物力学行为知之甚少。本研究旨在通过增量应力松弛实验确定单轴张力下离体大鼠皮下组织的弹性和粘弹性机械特性。组织的弹性响应是线性的，瞬时拉伸模量和平衡拉伸模量分别为4.77 kPa和2.75 kPa。使用 5 参数 Maxwell 实体模型，材料参数 mu(1) = 0.95 +/- 0.24 Ns/m 和 mu(2) = 8.49 +/- 2.42 Ns/m 分别定义与时间常数 tau(1) M = 3.83 +/- 0.15 sec 和 tau(2) M = 30.15 +/- 3.16 sec 相关的粘度系数。使用连续弛豫函数，参数 C = 0.25 +/- 0.12、tau(1C) = 1.86 +/- 0.34 秒和 tau(2C) = 110.40 +/- 25.59 秒定义弛豫谱的幅度和频率限制。这项研究为皮下结缔组织的应力应变行为提供了基线信息。我们的结果强调了疏松结缔组织和高承载结缔组织之间机械行为的差异，并表明疏松结缔组织可能具有向这些组织内存在的丰富的成纤维细胞、免疫细胞、血管细胞和神经细胞传递机械信号的功能。
Subcutaneous tissue is part of a bodywide network of "loose" connective tissue including interstitial connective tissues separating muscles and surrounding all nerves and blood vessels. Despite its ubiquitous presence in the body and its potential importance in a variety of therapies utilizing mechanical stretch, as well as normal movement and exercise, very little is known about loose connective tissue's biomechanical behavior. This study aimed to determine elastic and viscoelastic mechanical properties of ex-vivo rat subcutaneous tissue in uniaxial tension with incremental stress relaxation experiments. The elastic response of the tissue was linear, with instantaneous and equilibrium tensile moduli of 4.77 kPa and 2.75 kPa, respectively. Using a 5 parameter Maxwell solid model, material parameters mu(1) = 0.95 +/- 0.24 Ns/m and mu(2) = 8.49 +/- 2.42 Ns/m defined coefficients of viscosity related to time constants tau(1) M = 3.83 +/- 0.15 sec and tau(2) M = 30.15 +/- 3.16 sec, respectively. Using a continuous relaxation function, parameters C = 0.25 +/- 0.12, tau(1C) = 1.86 +/- 0.34 sec, and tau(2C) = 110.40 +/- 25.59 sec defined the magnitude and frequency limits of the relaxation spectrum. This study provides baseline information for the stress-strain behaviors of subcutaneous connective tissue. Our results underscore the differences in mechanical behaviors between loose and high-load bearing connective tissues and suggest that loose connective tissues may function to transmit mechanical signals to and from the abundant fibroblasts, immune, vascular, and neural cells present within these tissues.