Enhanced preattentive central nervous system reactivity in irritable bowel syndrome
Enhanced preattentive central nervous system reactivity in irritable bowel syndrome
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DOI：
10.1111/j.1572-0241.2002.07024.x
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发表时间：
2002-11-01
影响因子：
9.8
通讯作者：
Mayer, EA
中科院分区：
文献类型：
--
作者：
Berman, SM;Naliboff, BD;Mayer, EA
目的：肠易激综合征（IBS）是一种常见的功能性疾病，其特征是对内脏传入信号的感知敏感性增强和过度警觉。我们假设，IBS患者的反应性增加是一个普遍的现象，适用于刺激以外的内脏，并试图证明增加反应的声音测量的P1头皮potential.METHODS：事件相关电位记录从IBS患者和对照组在一个听觉任务，需要检测罕见的音高目标在指定的耳朵。视觉词作为目标在一个额外的block.RESULTS：与对照组相比，IBS患者显示了强大的增加幅度的PI头皮电位引起的出席和无人值守的sounds.CONCLUSIONS：增强PI表示前注意中枢神经系统disabituation在响应重复的声音。中枢神经系统反应性的普遍性注意力前增加可能是IBS与这些患者中经常共同发生的几种焦虑症共有的特征。(C)2002年，我胃肠病学。
OBJECTIVE: Irritable bowel syndrome (IBS) is a common functional disorder characterized by enhanced perceptual sensitivity and hypervigilance toward afferent signals from the viscera. We hypothesize that the increased responsiveness of IBS patients is a generalized phenomenon applying to stimuli other than visceral and attempt to demonstrate increased responsiveness to sounds as measured by the P1 scalp potential.METHODS: Event-related potentials were recorded from IBS patients and control subjects in an auditory task requiring detection of rare pitch targets in a designated ear. Visual words served as targets in an additional block.RESULTS: Compared to control subjects, IBS patients displayed a robust increase in the amplitude of the PI scalp potential elicited by both attended and unattended sounds.CONCLUSIONS: Enhanced PI indicates preattentive central nervous system dishabituation in response to repeated sounds. A generalized preattentive increase in central nervous system reactivity may be a feature that IBS shares with several anxiety disorders that frequently co-occur in these patients. (C) 2002 by Am. Coll. of Gastroenterology.