Reactive Mechanism of Cognitive Control System
Reactive Mechanism of Cognitive Control System
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DOI：
10.1093/cercor/bhq013
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发表时间：
2010-11-01
期刊：
影响因子：
3.7
通讯作者：
Sakai, Katsuyuki
中科院分区：
文献类型：
--
作者：
Morishima, Yosuke;Okuda, Jiro;Sakai, Katsuyuki
前额叶皮质(PFC)被认为在感觉刺激呈现之前调节神经网络状态，有利于任务相关感觉信息的处理。然而，由于感觉信息到达时神经活动的内在波动，这种主动控制机制并不总是优化网络状态。在本研究中，我们研究了一种额外的控制机制，在该机制中，调节行为的控制过程被调整为对感觉信息的神经表征的逐次尝试的波动。我们要求正常的人类受试者执行Stroop任务的一个变体。使用功能磁共振成像，我们在单次试验的基础上，通过计算任务相关和任务无关感觉区域之间的激活差异，分离出感觉加工阶段的认知冲突。仅在不一致的试验中，背外侧PFC(DLPFC)的激活与感觉冲突的神经估计是一致的。此外，在快速反应的高感觉冲突试验中，DLPFC和前扣带皮质(ACC)之间的耦合更紧密。结果表明，虽然感觉冲突的检测是由DLPFC实现的，但在线行为调节是通过DLPFC和ACC之间的交互机制来实现的。
The prefrontal cortex (PFC) is thought to modulate the neural network state in favor of the processing of task-relevant sensory information prior to the presentation of sensory stimuli. However, this proactive control mechanism cannot always optimize the network state because of intrinsic fluctuation of neural activity upon arrival of sensory information. In the present study, we have investigated an additional control mechanism, in which the control process to regulate the behavior is adjusted to the trial-by-trial fluctuation in neural representations of sensory information. We asked normal human subjects to perform a variant of the Stroop task. Using functional magnetic resonance imaging, we isolated cognitive conflict at a sensory processing stage on a single-trial basis by calculating the difference in activation between task-relevant and task-irrelevant sensory areas. Activation in the dorsolateral PFC (DLPFC) covaried with the neural estimate of sensory conflict only on incongruent trials. Also, the coupling between the DLPFC and anterior cingulate cortex (ACC) was tighter on high-sensory conflict trials with fast response. The results suggest that although detection of sensory conflict is achieved by the DLPFC, online behavioral adjustment is achieved by interactive mechanisms between the DLPFC and ACC.