Reduced brain resting-state network specificity in infants compared with adults.
Reduced brain resting-state network specificity in infants compared with adults.
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DOI：
10.2147/ndt.s63773
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发表时间：
2014
影响因子：
3.2
通讯作者：
Tregellas JR
中科院分区：
文献类型：
--
作者：
Wylie KP;Rojas DC;Ross RG;Hunter SK;Maharajh K;Cornier MA;Tregellas JR
婴儿休眠状态网络不会表现出与幼儿和成人相同的连接模式。当前的脑发育理论强调区域和网络专业化的发展进程。我们比较了婴儿和成人的功能连接，预测与成人相比，婴儿将表现出较少的区域特异性和更多的网络通信。对12名健康足月婴儿和17名成人进行了静息功能磁共振成像。使用独立成分分析提取静息状态网络，然后在成人组和婴儿组之间进行比较。成人在默认模式网络的后扣带皮质节点表现出更强的连通性，而婴儿在内侧前额叶/前扣带皮质的连通性比成年人更高。在以前与各种网络相关的结构内，成人连接性通常高于婴儿连接性，而在这些结构之外，婴儿连接性往往更高。婴儿的网际网络通信显著高于成年人。我们将这些发现解释为与证据一致，该证据表明，静息态网络的发展与空间专一性的增加有关，可能反映了相应的区域功能专门化及其通过经验的相互联系。
Infant resting-state networks do not exhibit the same connectivity patterns as those of young children and adults. Current theories of brain development emphasize developmental progression in regional and network specialization. We compared infant and adult functional connectivity, predicting that infants would exhibit less regional specificity and greater internetwork communication compared with adults. Functional magnetic resonance imaging at rest was acquired in 12 healthy, term infants and 17 adults. Resting-state networks were extracted, using independent components analysis, and the resulting components were then compared between the adult and infant groups. Adults exhibited stronger connectivity in the posterior cingulate cortex node of the default mode network, but infants had higher connectivity in medial prefrontal cortex/anterior cingulate cortex than adults. Adult connectivity was typically higher than infant connectivity within structures previously associated with the various networks, whereas infant connectivity was frequently higher outside of these structures. Internetwork communication was significantly higher in infants than in adults. We interpret these findings as consistent with evidence suggesting that resting-state network development is associated with increasing spatial specificity, possibly reflecting the corresponding functional specialization of regions and their interconnections through experience.