Maternal transmission of resistance to development of allergic airway disease
Maternal transmission of resistance to development of allergic airway disease
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DOI：
10.4049/jimmunol.179.2.1282
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发表时间：
2007-07-15
影响因子：
4.4
通讯作者：
Puddington, Lynn
中科院分区：
文献类型：
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作者：
Matson, Adam P.;Zhu, Li;Puddington, Lynn
已知父母的表型影响过敏性疾病的遗传，如过敏性哮喘，母亲病史是后代比父亲病史更重要的风险因素。我们假设，在怀孕期间回忆Th1或Th2类型的免疫反应将导致母体因素的转移，这些因素将对后代的免疫反应发展产生不同的影响。断奶后，在后代中评估过敏性呼吸道疾病(人类哮喘的小鼠模型)的易感性和严重程度，通过OVA-A1(OH)3免疫和雾化OVA激发引起的疾病。我们发现，与Th2偏向的OVA免疫母亲或幼稚母亲的后代相比，具有Th1偏向OVA免疫的母亲在孕期接受回忆性气溶胶攻击的后代的Ag特异性IgE水平和气道嗜酸性粒细胞水平较低。有趣的是，对异种白蛋白(BSA)有Th1型免疫的母亲的后代不能预防OVA诱导的过敏性呼吸道疾病。这些发现表明，在这种母体Th1型免疫模型中，母体对发生过敏性呼吸道疾病的保护转移到后代是抗原特异性的。
Parental phenotype is known to influence the inheritance of atopic diseases, such as allergic asthma, with a maternal history being a more significant risk factor for progeny than paternal history. We hypothesized that recall Th1- or Th2-type immune responses during pregnancy would result in transfer of maternal factors that would differentially impact development of immune responsiveness in offspring. Following weaning, susceptibility and severity of allergic airway disease (a murine model of human asthma) was evaluated in progeny, disease being elicited by immunization with OVA-A1(OH)3 and challenge with aerosolized OVA. We found that progeny of mothers with Th1-biased immunity to OVA subjected to recall aerosol challenge during pregnancy had reduced levels of Ag-specific IgE and airway eosinophilia compared with progeny of mothers with Th2-biased immunity to OVA or naive mothers. Interestingly, progeny of mothers with Th1-type immunity to a heterologous albumin, BSA, were not protected from developing OVA-induced allergic airway disease. These findings demonstrated that maternal transfer of protection from development of allergic airway disease to offspring in this model of maternal Th1-type immunity was Ag specific.