The influence of insulin on circulating ghrelin
The influence of insulin on circulating ghrelin
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DOI：
10.1152/ajpendo.00569.2001
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发表时间：
2003-02-01
影响因子：
5.1
通讯作者：
Sherwin, RS
中科院分区：
文献类型：
--
作者：
Flanagan, DE;Evans, ML;Sherwin, RS
Ghrelin是一种新的作用于垂体和下丘脑生长激素促分泌素受体的多肽。它可能作为生长激素分泌的第三种生理调节剂，沿着生长激素释放激素和生长抑素。除了生长激素释放肽对GH轴的作用外，它似乎在能量稳态的确定中起作用。虽然进食抑制生长激素释放肽的产生和禁食刺激生长激素释放肽的释放，控制这一过程的潜在机制仍不清楚。本研究的目的是通过使用阶梯式高胰岛素血糖钳夹技术来检验高胰岛素血症或低血糖可能影响生长激素释放肽产生的假设。胃饥饿素水平在钳夹前保持稳定，但在正常血糖期间对胰岛素输注反应迅速下降（基线胃饥饿素207+/-12 vs. 169+/-10 fmol/ml，t=30 min，P
Ghrelin is a novel peptide that acts on the growth hormone (GH) secretagogue receptor in the pituitary and hypothalamus. It may function as a third physiological regulator of GH secretion, along with GH-releasing hormone and somatostatin. In addition to the action of ghrelin on the GH axis, it appears to have a role in the determination of energy homeostasis. Although feeding suppresses ghrelin production and fasting stimulates ghrelin release, the underlying mechanisms controlling this process remain unclear. The purpose of this study was to test the hypotheses, by use of a stepped hyperinsulinemic eu-hypo-hyperglycemic glucose clamp, that either hyperinsulinemia or hypoglycemia may influence ghrelin production. Having been stable in the period before the clamp, ghrelin levels rapidly fell in response to insulin infusion during euglycemia (baseline ghrelin 207+/-12 vs. 169+/-10 fmol/ml at t=30 min, P