Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype.
Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype.
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DOI：
10.1016/j.freeradbiomed.2017.03.020
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发表时间：
2017-08
影响因子：
7.4
通讯作者：
Asmis R
中科院分区：
文献类型：
--
作者：
Kim HS;Asmis R
MAPK信号通路在病原体、信号分子和环境信号对单核细胞和巨噬细胞的激活以及巨噬细胞功能和可塑性的调节中起着重要作用。MAPK磷酸酶1(MKP-1)是单核细胞和巨噬细胞中MAPK信号的主要反向调节因子。代谢应激导致单核细胞和巨噬细胞中MKP-1的缺失，导致单核细胞黏附和迁移的失调，并导致功能障碍的、致动脉粥样硬化的单核细胞来源的巨噬细胞。在这里，我们综述了这种受氧化还原调节的双特异性MAPK磷酸酶的性质以及MKP-1在单核/巨噬细胞生物学和心血管疾病中的作用。
MAPK pathways play a critical role in the activation of monocytes and macrophages by pathogens, signaling molecules and environmental cues and in the regulation of macrophage function and plasticity. MAPK phosphatase 1 (MKP-1) has emerged as the main counter-regulator of MAPK signaling in monocytes and macrophages. Loss of MKP-1 in monocytes and macrophages in response to metabolic stress leads to dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the properties of this redox-regulated dual-specificity MAPK phosphatase and the role of MKP-1 in monocyte and macrophage biology and cardiovascular diseases.