Direct Conversion of Thiols to Sulfonyl Chlorides and Sulfonamides
Direct Conversion of Thiols to Sulfonyl Chlorides and Sulfonamides
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DOI：
10.1021/jo901924m
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发表时间：
2009-12-18
影响因子：
3.6
通讯作者：
Soheilizadt, Mehdi
中科院分区：
文献类型：
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作者：
Bahrami, Kiumars;Khodaei, Mohammad M.;Soheilizadt, Mehdi
H_2O_2与SOCl_2的组合被证明是通过氧化氯化将硫醇衍生物直接氧化转化为相应的高纯度磺酰氯的高反应性试剂。在与胺反应时，在非常短的反应时间内以优异的产率获得相应的磺酰胺。
H2O2 in combination with SOCl2 proved to be it highly reactive reagent for the direct oxidative conversion of thiol derivatives to the corresponding sulfonyl chlorides with high purity through oxidative chlorination. Upon reaction with amines, the corresponding sulfonamides were obtained in excellent yields and in very short reaction times.