Malaria vaccines: the 60-year journey of hope and final success-lessons learned and future prospects.
Malaria vaccines: the 60-year journey of hope and final success-lessons learned and future prospects.
复制标题
疟疾疫苗：希望和最终成功的60年旅程学习和未来的前景。
DOI：
10.1186/s41182-023-00516-w
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发表时间：
2023-05-17
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
世界在战胜疟疾方面取得了长足进步，尽管世界人口中约有一半仍面临感染疟疾的风险。研制有效的疟疾疫苗对医学来说是一个巨大的挑战。2021年，世界卫生组织（WHO）批准了第一种疟疾疫苗RTS，S/AS 01疫苗（Mosquirix™）广泛使用。这篇综述强调了疟疾疫苗的发展历史，不同的方法和类型，以及迄今为止的文献。它涵盖RTS，S/AS 01的发展阶段，并建议其部署步骤。该综述探讨了其他潜在的候选疫苗及其现状，并提出了进一步开发的选择。它还建议疫苗在消灭疟疾方面的未来作用。关于RTS，S疫苗如何广泛使用以及如何最好地利用它来造福脆弱社区，仍然存在问题。疟疾疫苗的开发已经有近60年的历史。RTS，S/AS 01疫苗现已获得批准，但不能作为一种独立的解决方案。应继续开发有希望的候选疫苗，如R21、PfSPZ和间日疟原虫疫苗。多组分疫苗可能是实现消灭疟疾的其他疟疾控制技术的有益补充。
The world has made great strides towards beating malaria, although about half of the world population is still exposed to the risk of contracting malaria. Developing an effective malaria vaccine was a huge challenge for medical science. In 2021 the World Health Organization (WHO) approved the first malaria vaccine, RTS,S/AS01 vaccine (Mosquirix™), for widespread use. This review highlights the history of development, and the different approaches and types of malaria vaccines, and the literature to date. It covers the developmental stages of RTS,S/AS01 and recommends steps for its deployment. The review explores other potential vaccine candidates and their status, and suggests options for their further development. It also recommends future roles for vaccines in eradicating malaria. Questions remain on how RTS,S vaccine will work in widespread use and how it can best be utilized to benefit vulnerable communities. Malaria vaccines have been in development for almost 60 years. The RTS,S/AS01 vaccine has now been approved, but cannot be a stand-alone solution. Development should continue on promising candidates such as R21, PfSPZ and P. vivax vaccines. Multi-component vaccines may be a useful addition to other malaria control techniques in achieving eradication of malaria.
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影响因子：
30.3
作者：
Butler NS;Schmidt NW;Vaughan AM;Aly AS;Kappe SH;Harty JT
通讯作者：
Harty JT
影响因子：
3.8
作者：
Arévalo-Herrera M;Vásquez-Jiménez JM;Lopez-Perez M;Vallejo AF;Amado-Garavito AB;Céspedes N;Castellanos A;Molina K;Trejos J;Oñate J;Epstein JE;Richie TL;Herrera S
通讯作者：
Herrera S
影响因子：
3
作者：
Villasis E;Lopez-Perez M;Torres K;Gamboa D;Neyra V;Bendezu J;Tricoche N;Lobo C;Vinetz JM;Lustigman S
通讯作者：
Lustigman S
DOI：
10.4269/ajtmh.2007.77.289
发表时间：
2007-12-01
影响因子：
3.3
作者：
Ballou, W. Ripley;Cahill, Conor P.
通讯作者：
Cahill, Conor P.
影响因子：
158.5
作者：
Abdulla, Salim;Oberholzer, Rolf;Tanner, Marcel
通讯作者：
Tanner, Marcel