Rationales, design and recruitment for the Elfe longitudinal study
Rationales, design and recruitment for the Elfe longitudinal study
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DOI：
10.1186/1471-2431-9-58
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发表时间：
2009-09-21
期刊：
影响因子：
2.4
通讯作者：
Leridon, Henri
中科院分区：
文献类型：
--
作者：
Vandentorren, Stephanie;Bois, Corinne;Leridon, Henri
背景资料：许多因素在童年时期同时作用，影响健康状况、生活机会和幸福感，包括产前影响、早期生活的环境污染物、健康状况以及家庭和学校的社会影响。一个队列研究是必要的，解开这些影响，探索attribute.Methods：Elfe将是一个全国性的代表性队列的20 000名儿童从出生到成年，使用多学科的方法。该队列将以统计经研所常设人口小组为基础，该小组利用人口普查数据和民事记录建立。确定样本量是为了符合代表性标准并获得一些流行率估计值，同时也是为了解决低暴露/罕见效应的研究领域。该队列将基于面对面或电话访谈（出生时和每年）以及医学访谈（2岁时）和检查（6岁时）的重复调查。此外，将在出生时采集生物样本，以评估胎儿对有毒物质的暴露，环境传感器将放置在儿童家中。试点研究已于2007年启动（500名儿童），总体接受率为55%，目前正在进行中，两年期调查将于今年10月进行。纵向研究将提供一个独特的数据来源，以分析儿童在其环境中的发展，研究在直至成年的整个生命过程中相互作用的各种因素，并确定童年经历对个人的生理、心理、社会和职业发展的影响。
Background: Many factors act simultaneously in childhood to influence health status, life chances and well being, including pre-birth influences, the environmental pollutants of early life, health status but also the social influences of family and school. A cohort study is needed to disentangle these influences and explore attribution.Methods: Elfe will be a nationally representative cohort of 20 000 children followed from birth to adulthood using a multidisciplinary approach. The cohort will be based on the INSEE Permanent Demographic Panel (EDP) established using census data and civil records. The sample size has been defined in order to match the representativeness criteria and to obtain some prevalence estimation, but also to address the research area of low exposure/rare effects. The cohort will be based on repeated surveys by face to face or phone interview (at birth and each year) as well as medical interview (at 2 years) and examination (at 6 years). Furthermore, biological samples will be taken at birth to evaluate the foetal exposition to toxic substances, environmental sensors will be placed in the child's homes. Pilot studies have been initiated in 2007 (500 children) with an overall acceptance rate of 55% and are currently under progress, the 2-year survey being carried out in October this year.Discussion: The longitudinal study will provide a unique source of data to analyse the development of children in their environment, to study the various factors interacting throughout the life course up to adulthood and to determine the impact of childhood experience on the individual's physical, psychological, social and professional development.