Regulation of Feeding Behavior and Energy Metabolism by Galanin-like Peptide (GALP): A Novel Strategy to Fight Against Obesity.
Regulation of Feeding Behavior and Energy Metabolism by Galanin-like Peptide (GALP): A Novel Strategy to Fight Against Obesity.
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DOI：
10.2174/1381612824666181106111623
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发表时间：
2019-01
影响因子：
3.1
通讯作者：
F. Takenoya;Satoshi Hirako;Nobuhiro Wada;N. Nonaka;T. Hirabayashi;H. Kageyama;S. Shioda
中科院分区：
文献类型：
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作者：
F. Takenoya;Satoshi Hirako;Nobuhiro Wada;N. Nonaka;T. Hirabayashi;H. Kageyama;S. Shioda
甘丙肽样肽（Galanin-like peptide，GALP）由60个氨基酸组成，其序列在物种间高度同源。GALP产生于下丘脑弓状核，具有多种生理作用，如调节摄食、能量代谢和生殖行为。含GALP的神经元表达瘦素受体，这些神经元在下丘脑中形成含有调节进食行为的各种肽的网络。最近的研究表明，GALP除了在食物摄入调节中的作用外，还具有中枢抗肥胖作用。此外，我们发现，呼吸商下降后不久，管理GALP进入侧脑室。这表明GALP给药加速了脂质代谢，并确定了该肽的新生理作用。本文就GALP调节摄食和能量代谢的机制作一综述。我们专注于通过自主神经系统调节外周组织脂质代谢的机制，并概述了GALP鼻腔给药的有效性及其临床应用的基础研究。
Galanin-like peptide (GALP) is composed of 60 amino acid residues and its sequence is highly homologous across species. GALP is produced in the hypothalamic arcuate nucleus and has diverse physiological effects such as the regulation of feeding, energy metabolism, and reproductive behavior. GALP-containing neurons express leptin receptors and these neurons form networks in the hypothalamus that contain various peptides that regulate feeding behavior. Recent studies have revealed that GALP has a central anti-obesity action in addition to its role in food intake regulation. Furthermore, we have found that the respiratory quotient declines shortly after administration of GALP into the lateral ventricle. This suggests that lipid metabolism is accelerated by GALP administration, and identifies a new physiological action for this peptide. In this review article, we summarize our recent research focusing on the mechanism whereby GALP regulates feeding and energy metabolism. We concentrate on the mechanism of regulation of lipid metabolism in peripheral tissues via the autonomic nervous system and outline the effectiveness of the nasal administration of GALP and basic research towards its clinical application.