Critical Problems Stalling Progress in Natural Bioactive Polysaccharide Research and Development
Critical Problems Stalling Progress in Natural Bioactive Polysaccharide Research and Development
复制标题
阻碍天然生物活性多糖研究和开发进展的关键问题
DOI：
10.1021/acs.jafc.8b00493
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发表时间：
2018-05-09
影响因子：
6.1
通讯作者：
Han, Quan-Bin
中科院分区：
文献类型：
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作者：
Han, Quan-Bin
天然多糖因其广泛的生物活性而日益受到食品和制药行业的重视。然而，样品制备和化学表征中使用的方法重复性差，阻碍了研究和产品开发。不标准化的质量反过来又破坏了了解它们通过口服剂量起作用的机制的努力，这对于实现多糖的全部有益潜力至关重要。一些科学家认为多糖是通过肠道直接吸收起作用的；然而，越来越多的证据表明，肠道微生物群和肠道佩耶尔补丁是它们如何工作的关键。
Natural polysaccharides are attracting increasing attention from food and pharmaceutical industries for their wide range of valuable biological activities. However, the poor repeatability of the methods used in sample preparation and chemical characterization is hampering both research and product development. The unstandardized quality, in turn, undermines efforts to understand the mechanism by which they work via oral dose, which is essential to realize the full beneficial potential of polysaccharides. Some scientists believe polysaccharides work by direct gut absorption; however, increasing evidence points to the gut microbiome and intestinal Peyer's patches as holding the keys to how they work.