Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy
Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy
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DOI：
10.1364/ol.34.003746
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发表时间：
2009-12-01
期刊：
影响因子：
3.6
通讯作者：
van Leeuwen, Ton G.
中科院分区：
文献类型：
--
作者：
Bosschaart, Nienke;Aalders, Maurice C. G.;van Leeuwen, Ton G.
低相干光谱(LCS)是一种光谱方法，通过结合反射光谱和低相干干涉测量，可以对吸收光谱进行定量和局部评估。我们描述了LCS在具有不同散射和吸收特性的组织模拟体模中的吸收系数(Mu(A))测量。我们使用LCS在455-680 nm的波长范围内，光谱分辨率为8 nm，获得了精度为+/-0.5 mm(1)的u(A)光谱。我们认为，LCS是一种很有前途的在体测定组织发色团浓度的技术。(C)2009年美国光学学会
Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (mu(a)) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455-680 nm wavelength range with a spectral resolution of 8 nm to obtain mu(a) spectra with +/- 0.5 mm (1) accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations. (C) 2009 Optical Society of America