Telomerase inhibition may contribute to accelerated mitochondrial aging induced by anti-retroviral HIV treatment
Telomerase inhibition may contribute to accelerated mitochondrial aging induced by anti-retroviral HIV treatment
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DOI：
10.1016/j.mehy.2013.04.028
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发表时间：
2013-08-01
影响因子：
4.7
通讯作者：
Bollmann, F. M.
中科院分区：
文献类型：
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作者：
Bollmann, F. M.
接受长期抗逆转录病毒治疗的艾滋病毒感染者往往会出现早衰。由核苷逆转录酶抑制剂（NRTI）诱导的加速线粒体衰老已被认为是这种现象的一部分。传统上，这被归因于这些药物对mtDNA聚合酶7的抑制，但也有人提出了其他解释。已知NRTIs不仅能抑制病毒逆转录酶，还能抑制人端粒酶。近年来，端粒酶的端粒外作用，包括保护线粒体DNA和功能，已逐渐被人们所认识。在本文中，我提出，抑制线粒体端粒酶活性的NRTI药物有助于线粒体毒性和过早老化治疗的HIV患者中看到的，并讨论了反对意见和实验测试的假设。(C)2013爱思唯尔有限公司保留所有权利。
HIV-infected individuals undergoing long-term anti-retroviral treatment tend to show premature senescence. Accelerated mitochondrial aging induced by nucleoside reverse transcriptase inhibitors (NRTIs) has been implicated as a part of this phenomenon. Traditionally, this has been attributed to inhibition of mtDNA polymerase 7 by these drugs, but alternative explanations have been proposed. It is known that NRTIs can not only inhibit viral reverse transcriptase, but also human telomerase. A number of extratelomeric roles of telomerase, including protection of mitochondrial DNA and function, have emerged recently. In this paper, I propose that inhibition of mitochondrial telomerase activity by NRTI drugs contributes to the mitochondrial toxicity and premature aging seen in treated HIV patients, and discuss objections and experimental testing of the hypothesis. (C) 2013 Elsevier Ltd. All rights reserved.