Total synthesis of dolabelide D
Total synthesis of dolabelide D
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DOI：
10.1021/ja058692k
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发表时间：
2006-03-08
影响因子：
15
通讯作者：
Leighton, JL
中科院分区：
文献类型：
--
作者：
Park, PK;O'Malley, SJ;Leighton, JL
第一个全合成多拉别利D（或任何密切相关的多拉别利）已经实现了最长的线性序列的17个步骤。合成的关键特征包括催化不对称硅烷醇解、串联甲硅烷基-巴豆基甲硅烷基化和Brook-like 1，4-碳-氧甲硅烷基迁移的应用。
The first total synthesis of dolabelide D (or of any of the closely related dolabelides) has been achieved with a longest linear sequence of 17 steps. Key features of the synthesis include an application of the catalytic asymmetric silane alcoholysis, the tandem silylformylation−crotylsilylation, and a Brook-like 1,4-carbon to oxygen silyl migration.