Insufficient Use of Corticosteroids without Immunosuppressants Results in Higher Relapse Rates in Takayasu Arteritis
Insufficient Use of Corticosteroids without Immunosuppressants Results in Higher Relapse Rates in Takayasu Arteritis
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DOI：
10.3899/jrheum.181219
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发表时间：
2020-02-01
影响因子：
3.9
通讯作者：
Harigae, Hideo
中科院分区：
文献类型：
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作者：
Mutoh, Tomoyuki;Shirai, Tsuyoshi;Harigae, Hideo
目标。虽然强的松龙(PSL)和免疫抑制剂是治疗大动脉炎(TA)的关键药物，但关于PSL的最佳剂量的证据有限。本研究的目的是探讨PSL的初始剂量与TA复发的相关性。从1990年到2015年，我们招募了105名符合日本循环学会和美国风湿病学会标准的TA患者。回顾分析TA患者的临床特点和转归。根据首次治疗的不同，评估无复发期。在中位随访56个月期间，96名接受免疫抑制治疗的患者中有57人(59.4%)复发。男性和发病年龄较早与复发显著相关。虽然每天30毫克(87.2%比52.6%)，但观察到的复发率显著高于
Objective. Although prednisolone (PSL) and immunosuppressants are key drugs for Takayasu arteritis (TA) treatment, there is limited evidence on the optimal PSL dose. The aim of this study was to investigate the correlation between the initial PSL dose and relapse in TA.Methods. We enrolled 105 patients with TA who satisfied the criteria of the Japanese Circulation Society and American College of Rheumatology from 1990 to 2015. The clinical characteristics and outcomes of patients with TA were retrospectively evaluated. The relapse-free period was assessed according to the difference in initial treatments.Results. Relapse was observed in 57 (59.4%) of 96 patients treated with immunosuppressive therapy at diagnosis during a median followup of 56 months. Male sex and younger age of onset were significantly associated with relapse. Although 30 mg/day (87.2% vs 52.6%), a significantly higher relapse rate was observed in the