Slippery Liquid-Attached Surface for Robust Biofouling Resistance
Slippery Liquid-Attached Surface for Robust Biofouling Resistance
复制标题
光滑的液体附着表面可实现强大的生物污垢抵抗力
DOI：
10.1021/acsbiomaterials.9b01323
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发表时间：
2020-01-01
影响因子：
5.8
通讯作者：
Xie, Xi
中科院分区：
文献类型：
--
作者：
Wu, Qianni;Yang, Chengduan;Xie, Xi
用于生物设备和生物植入物的材料通常由于蛋白质、细胞或细菌的非特异性黏附而遭受不必要但不可避免的生物污垢问题。人们一直在寻求减少生物污垢的化学涂层或物理策略，但仍然缺乏能够持久抵抗生物环境中污染的高度坚固的抗生物污垢表面。在这项研究中，我们开发了一种简单的方法，通过将类液体聚合物层连接到基质上来制备高度坚固的光滑和抗生物污垢的表面。这种光滑的液体附着(SLA)表面是通过一步平衡反应产生的，方法是将端甲氧基聚二甲基硅氧烷(PDMS-OCH3)聚合物刷子系在基板上，形成透明的“类液体”层。SLA表面对多种液体和小颗粒表现出良好的滑动性能，并具有抗生物污垢性能，防止小生物分子、蛋白质、细胞和细菌的长期黏附。此外，与需要微/纳米结构的超全向表面和充液多孔表面(滑块)相比，SLA层可以在光滑的表面上获得，并在磨损下保持其抗生物污垢能力并保持持久的稳定性。我们的研究提供了一种简单的方法来使表面具有强大的光滑和抗生物污垢性能，这是一种潜在的应用前景，包括医疗植入物和生物设备。
Materials for biodevices and bioimplants commonly suffer from unwanted but unavoidable biofouling problems due to the nonspecific adhesion of proteins, cells, or bacteria. Chemical coating or physical strategies for reducing biofouling have been pursued, yet highly robust antibiofouling surfaces that can persistently resist contamination in biological environments are still lacking. In this study, we developed a facile method to fabricate a highly robust slippery and antibiofouling surface by conjugating a liquid-like polymer layer to a substrate. This slippery liquid-attached (SLA) surface was created via a one-step equilibration reaction by tethering methoxy-terminated polydimethylsiloxane (PDMS-OCH3) polymer brushes onto a substrate to form a transparent "liquid-like" layer. The SLA surface exhibited excellent sliding behaviors toward a wide range of liquids and small particles and antibiofouling properties against the long-term adhesion of small biomolecules, proteins, cells, and bacteria. Moreover, in contrast to superomniphobic surfaces and liquid-infused porous surfaces (SLIPS) requiring micro/nanostructures, the SLA layer could be obtained on smooth surfaces and maintain its biofouling resistance under abrasion with persistent stability. Our study offers a simple method to functionalize surfaces with robust slippery and antibiofouling properties, which is promising for potential applications including medical implants and biodevices.