CLONING OF THE T-GENE REQUIRED IN MESODERM FORMATION IN THE MOUSE

CLONING OF THE T-GENE REQUIRED IN MESODERM FORMATION IN THE MOUSE
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DOI:
10.1038/343617a0
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发表时间:
1990-02-15
期刊:
影响因子:
64.8
通讯作者:
LEHRACH, H
LEHRACH, H
中科院分区:
综合性期刊1区
文献类型:
--
作者:
HERRMANN, BG;LABEIT, S;LEHRACH, H

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小鼠发育突变确定了中胚层形成的重要基因。缺乏正常基因活性的胚胎不能形成脊索、整个后区和allentois,并在妊娠10天左右死亡。我们结合分子和遗传技术分离了tgene,从而使分子工具可用于研究小鼠中胚层形成的过程。
The murine developmental mutationTidentifies an essential gene in mesoderm formation. Embryos lacking normal gene activity fail to form the notochord, the entire posterior region and the allan-tois, and die at about 10 days of gestation. We have isolated theTgene using a combination of molecular and genetic techniques, thus making molecular tools available to study processes underlying mesoderm formation in the mouse.