One-Pot Synthesis of Spirooxazino Derivatives via Enzyme- Initiated Multicomponent Reactions
One-Pot Synthesis of Spirooxazino Derivatives via Enzyme- Initiated Multicomponent Reactions
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DOI：
10.1002/adsc.201300965
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发表时间：
2014-03
影响因子：
5.4
通讯作者：
Junliang Wang;Xiao-Yang Chen;Qi Wu;Xianfu Lin
中科院分区：
文献类型：
--
作者：
Junliang Wang;Xiao-Yang Chen;Qi Wu;Xianfu Lin
A novel enzyme‐initiated multicomponent reaction from readily available aldehyde, nitrostyrene, cyclohexanone and acetamide substrates was discovered, enabling the facile construction of six new CC/N bonds and two rings in single step, one‐pot operation, for the synthesis of spirooxazino derivatives in moderate to high yields. Several methods such as isotope labelling and enzyme mutation were used to probe the possible mechanism of this complex synthesis.
