Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians
Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians
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DOI：
10.1111/j.1468-1331.2010.03185.x
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发表时间：
2011-07-01
影响因子：
5.1
通讯作者：
Hashizume, Y.
中科院分区：
文献类型：
--
作者：
Iwasaki, Y.;Mimuro, M.;Hashizume, Y.
背景：日本散发性克雅氏病(SCJD)与高加索人sCJD的临床病程是否不同，目前尚不清楚。为探讨日本人sCJD的临床病程，对29例日本MM1型sCJD患者的临床表现进行了回顾分析，并与高加索人sCJD结果进行了比较。结果：日本MMM1型sCJD患者至静止期的存活率与白人相似。然而，日本患者的总病程约为日本患者的3倍。结论：目前的观察表明，日本sCJD患者普遍表现出较长的病程，这是因为达到静止性沉默状态后的生存期较长。
Background: It is not known whether the clinical course of Japanese sporadic Creutzfeldt-Jakob disease (sCJD) cases differs from that of Caucasian sCJD cases.Patients and methods: To investigate the clinical course of Japanese sCJD, clinical findings from 29 patients with Japanese MM1-type sCJD were retrospectively evaluated and compared to Caucasian sCJD findings.Results: Survival of Japanese MM1-type sCJD up to the time of akinetic mutism state is similar to that of Caucasian subjects. However, the total disease duration of Japanese patients was approximately three times longer.Conclusions: The present observations indicate that Japanese sCJD cases generally show a longer disease duration because of the longer survival period after reaching the akinetic mutism state.