Mitochondrial division and fusion in metabolism.
Mitochondrial division and fusion in metabolism.
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DOI：
10.1016/j.ceb.2015.02.001
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发表时间：
2015-04
影响因子：
7.5
通讯作者：
Sesaki H
中科院分区：
文献类型：
--
作者：
Roy M;Reddy PH;Iijima M;Sesaki H
线粒体控制许多代谢过程。此外，线粒体感知代谢状态并改变其功能以调节能量产生、细胞死亡和产热。最近的研究表明，通过分裂和融合进行的线粒体结构重塑对细胞器的功能至关重要。线粒体分裂和融合的异常与代谢性疾病如糖尿病和肥胖症的病理生理学有关，这一点也变得很清楚。在这里，我们讨论了目前的线粒体动力学机制及其在细胞和有机体代谢中的作用。
Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle’s function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.