Reverse engineering the kidney: modelling calcium oxalate monohydrate crystallization in the nephron
Reverse engineering the kidney: modelling calcium oxalate monohydrate crystallization in the nephron
复制标题
DOI：
10.1007/s11517-010-0617-y
复制
发表时间：
2010-07-01
影响因子：
3.2
通讯作者：
Wilkins, T. A.
中科院分区：
文献类型：
--
作者：
Borissova, A.;Goltz, G. E.;Wilkins, T. A.
采用工业结晶模型模拟了单肾单位（远曲小管）切片中一水草酸钙的结晶过程。肾单位流体动力学表示为具有变化体积的结晶器/分离器系列，以允许沿着小管沿着去除水。该模型集成了结晶动力学和晶体尺寸分布，并允许草酸钙浓度分布和成核和生长速率的预测。草酸钙晶体成核的临界过饱和比为2，平均晶体尺寸为1 μ m。晶体生长级数为2.2，表明晶体生长和晶体生长分散的表面整合机制。该模型允许探索改变输入草酸钙浓度和水提取速率的效果，模拟结石形成的真实的生活压力源，如饮食负荷和脱水。
Crystallization of calcium oxalate monohydrate in a section of a single kidney nephron (distal convoluted tubule) is simulated using a model adapted from industrial crystallization. The nephron fluid dynamics is represented as a crystallizer/separator series with changing volume to allow for water removal along the tubule. The model integrates crystallization kinetics and crystal size distribution and allows the prediction of the calcium oxalate concentration profile and the nucleation and growth rates. The critical supersaturation ratio for the nucleation of calcium oxalate crystals has been estimated as 2 and the mean crystal size as 1 mu m. The crystal growth order, determined as 2.2, indicates a surface integration mechanism of crystal growth and crystal growth dispersion. The model allows the exploration of the effect of varying the input calcium oxalate concentration and the rate of water extraction, simulating real life stressors for stone formation such as dietary loading and dehydration.