The initial prodrome in psychosis: Descriptive and qualitative aspects
The initial prodrome in psychosis: Descriptive and qualitative aspects
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DOI：
10.3109/00048679609062654
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发表时间：
1996-10-01
影响因子：
4.6
通讯作者：
McGorry, PD
中科院分区：
文献类型：
--
作者：
Yung, AR;McGorry, PD
目的：本研究旨在采用回顾性方法详细描述首发精神病患者的前驱症状。这最初的前驱症状，在第一次精神病发作前的干扰期，是潜在的重要早期干预，生物标志物的识别，并了解成为psycho.Method的过程：一个连续的系列21例首次发作的患者被招募从早期精神病预防和干预中心，一个专门的服务，为年轻人年龄在16岁至30岁之间的首次发作精神病。受试者进行了采访，在急性发作后的恢复阶段，有关期间导致的精神病，使用相结合的非结构化和半结构化techniques.Results：一个广泛的变化的现象和序列模式被发现，与症状是一个混合物的衰减精神病症状，神经质和情绪相关的症状，和行为的变化。症状往往是禁用和一些，如自杀的想法，可能危及生命。结论：研究结果突出的信息，已导致忽视早期的精神病前驱症状的现象学研究，而不是专注于行为特征的损失。基础工作已经奠定了更好的方法来评估和测量的第一精神病probability的发展，越来越重视经验的现象。这有可能导致早期识别和更准确地预测随后的精神病，以及更深入地了解精神病性障碍发作的神经生物学。
Objective: This study aimed to describe in detail, using a retrospective approach, the prodromal symptoms in first-episode psychosis patients. This initial prodrome, the period of disturbance preceding a first psychotic episode, is potentially important for early intervention, identification of biological markers, and understanding the process of becoming psychotic.Method: A consecutive series of 21 first-episode patients was recruited from the Early Psychosis Prevention and intervention Centre, a specialised service for young people aged between 16 and 30 with first-episode psychosis. Subjects were interviewed in the recovery phase after the acute episode, about the period leading up to the psychosis, using a combination of unstructured and semi-structured techniques.Results: A wide variability of phenomena and sequence patterns was found, with symptoms being a mixture of attenuated psychotic symptoms, neurotic and mood-related symptoms, and behavioural changes. Symptoms were often disabling and some, such as suicidal thoughts, potentially life-threatening.Conclusions: The findings highlight the loss of information that has resulted from disregarding early phenomenological studies of the psychotic prodrome and instead focussing on behavioural features. The ground work has been laid for the development of better methodologies for assessing and measuring first psychotic prodromes with increased emphasis on experiential phenomena. This has the potential to lead to the early recognition and more accurate prediction of subsequent psychosis, as well as a deeper understanding of the neurobiology of the onset of psychotic disorder.