Drosophila neuromuscular synapse assembly and function require the TGF-β type I receptor saxophone and the transcription factor mad
Drosophila neuromuscular synapse assembly and function require the TGF-β type I receptor saxophone and the transcription factor mad
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DOI：
10.1002/neu.10189
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发表时间：
2003-05-01
期刊：
影响因子：
--
通讯作者：
Selleck, SB
中科院分区：
文献类型：
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作者：
Rawson, JM;Lee, M;Selleck, SB
转化生长因子-β(TGF-β)是一个分泌蛋白超家族，在构型和细胞分裂调控中具有不同功能。在脊椎动物和无脊椎动物系统中，转化生长因子-β信号与突触组装和可塑性有关。最近，果蝇的愿望思维基因编码了一种与BMP II型受体相关的蛋白质，它被证明是神经肌肉接头(NMJ)正常功能和发育所必需的。这些发现表明，转化生长因子-β相关的配体激活了涉及I型和II型受体以及Smad转录因子家族的信号级联，以协调NMJ的组装。在这里，我们证明了转化生长因子-βI型受体萨克斯管和下游转录因子妈妈抗DPP(Mad)对于果蝇NMJ的正常结构和功能发育是必不可少的，NMJ是一种表现出活性依赖性可塑性的突触。(C)2003年威利期刊公司。
Transforming growth factor-betas (TGF-beta) comprise a superfamily of secreted proteins with diverse functions in patterning and cell division control. TGF-beta signaling has been implicated in synapse assembly and plasticity in both vertebrate and invertebrate systems. Recently, wishful thinking, a Drosophila gene that encodes a protein related to BMP type II receptors, has been shown to be required for the normal function and development of the neuromuscular junction (NMJ). These findings suggest that a TGF-beta-related ligand activates a signaling cascade involving type I and II receptors and the Smad family of transcription factors to orchestrate the assembly of the NMJ. Here we demonstrate that the TGF-beta type I receptor Saxophone and the downstream transcription factor Mothers against dpp (Mad) are essential for the normal structural and functional development of the Drosophila NMJ, a synapse that displays activity-dependent plasticity. (C) 2003 Wiley Periodicals, Inc.